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Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma. It also may be possible to improve treatment by focusing on selective regional effects of drugs or drug delivery. Sanitary condition and productivity of a farm raising laying hens free of leukosis

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It offers easy access for collecting clinical cases of interest since a database function for research purposes is also incorporated. Outcomes of the SWOT analysis resulted in the establishment of department goals and objectives, as well as staff empowerment and increased cohesiveness. By treating nonsensitized C57BL/6J spleen derived lymphocytes with EL-4 tumor cell directed xenogeneic extracted RNA we were able to monitor early changes in cellular DNA content by flow cytometric (FCM) analysis and 3H-thymidine uptake.

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When bacteriophage T7 is plated out with its host, Escherichia coli, it establishes a constant-velocity infection wave, which is driven by an autocatalytic reaction-diffusion mechanism. The proposed C-mode contour modeling may provide clinically useful images of SoIs even in eyes with severe pathologic changes in which segmentation algorithms fail. Dynamics of vortex liquids in Ginzburg-Landau theories with applications to superconductivity.

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An adult red baboon (Papio cynocephalus papio) had a severe disseminated case of African histoplasmosis (Histoplasma capsulatum var. The findings suggest that representative gene expression profiles can be generated from human oocytes for comparative purposes following L-amp and hybridization to microarray. Classroom sessions were conducted to improve sun protection knowledge, foster more positive attitudes about hat use, and change the subjective norm of wearing hats when at school.

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Here we discuss how host-pathogen interaction, microbial interspecies interaction, and metabolic heterogeneity contribute to the success or failure of antibiotic therapy. Non-ischaemic cardiomyopathy, sudden death and implantable defibrillators: a review and meta-analysis. The accommodating ring-haptic IOLs did not perform better than the conventional plate-haptic IOL. Twenty-four specimens from distal tracheoesophageal fistulas of patients with EA-TEF (EA-TEF group) and 10 esophageal specimens from neonates who died of nonesophageal diseases (control group) were studied.

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We focus on the aorta and on the pressure at the ventricular-aortic interface, which epidemiological studies demonstrate to play a key role in cardiovascular diseases. Of 14 type IIa mutants, at least 6 were defective in phage DNA synthesis and 2 were defective in the synthesis of head proteins. The emerging field of lipidomics, driven by technological advances in lipid analysis, provides greatly enhanced opportunities to characterize, on a quantitative or semi-quantitative level, the entire spectrum of lipids, or lipidome, in specific cell types. Moreover we proved that PLL binding induces domain formation in the gel state of mixed DPPC/DPPG or DMPC/DPPG membranes as well as lipid remixing in the liquid-crystalline state.

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Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. In addition, the interdependence of the paranasal sinuses with other parts of the complex strongly indicates a functional role for them in nasal complex/upper respiratory functions. The limited host range AB3 strain of Agrobacterium tumefaciens induces tumors by transferring two T-regions, TA and TB. It is now debated whether the screening of heavy smokers for lung cancer with low dose computed tomography (low dose CT) might lower their mortality due to lung cancer. Histological analysis demonstrated fewer injured villi in the intraluminal-ANGD treated rats compared with those in the control rats.

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The ability to render form introduces new opportunities to touch, grasp, and manipulate dynamic physical content and tangible objects, in both nearby and remote environments. Humoral factor study of natural immunity in Sonne and Flexner dysenteries MR imaging findings corresponding to the 2009 revised International Federation of Gynecology and Obstetrics staging of gynecologic malignancies are also described in detail, highlighting possible pearls and pitfalls of staging. In contrast, LAMP-1 and LAMP-2 double-deficient fibroblasts failed to kill engulfed Neisseria gonorrhoeae.

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The mechanism may be important in the proarrhythmia effects of drugs that prolong repolarization and in the bradycardia-tachycardia syndrome. Cleavage at these sites is predicted to disrupt the structure and function of the fibrillin-rich microfibrils. As predicted, the typical female advantage was observed for the peripersonal OLMT. Evidence of unique-parity band structure in neutron-rich odd-A Ru isotopes. Replacement of L-proline by L-glutamate or L-pyroglutamate resulted in dipeptides which were more potent in morphine withdrawal than was Z-prolyl-D-leucine.

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A total of 133 patients with DHF and 118 age- and gender-matched control subjects were studied. Non-arteritic anterior ischaemic optic neuropathy and presumed sleep apnoea syndrome screened by the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ). Additionally, we outline the recent progress in the field, for example, in proteomics, which will allow the development of new biomarkers of sperm function. Within 10 min after antigen infusion, mainly leukotriene C4, but also leukotriene D4 and N-acetyl-leukotriene E4, appeared in the bile. Genetic correlations between male reproductive traits and weights ranged from .24 to .52 for the temperate breeds and were higher (.65 to .69) for Zebu crosses.

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Is aortic valve resistance more clinically meaningful than valve area in aortic stenosis? Secondary end points were progression-free survival (PFS), objective response rate (ORR), and safety.

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Toxic effects of octylphenol on cultured rat spermatogenic cells and Sertoli cells. In ALL blasts, the p53 tumor suppressor is the primary regulator of the apoptotic response to genotoxic chemotherapy, which is predictive of outcome. cAMP activates PKA by dissociating the regulatory subunit from the catalytic subunit.

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Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution. Enoxaparin, a low molecular weight fractionated heparin, has shown to be associated with a greater clinical efficacy, superior to that achieved with conventional heparin anticoagulation or treatment with aspirin, and probably should be considered as the antithrombotic of choice. Adsorptive separation of chiral molecules is a powerful technique that has long been used in the chemical and pharmaceutical industries. This retrospective study aimed to conduct a cephalometric evaluation of the skeletal, dental and soft tissue effects resulting from treatment of adult patients presenting Class II malocclusion, performed with a Mandibular Protraction Appliance (MPA) combined with a fixed orthodontic appliance. Development of OAD in the mouse trachea transplant model is primarily dependent on CD40L and is relatively CD28 independent.

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Mice were made physically dependent on ethanol by a 3-day alcohol inhalation regimen, using pyrazole to stabilize blood ethanol concentrations. Because it is a rare life-threatening condition with a high mortality rate in the pediatric population, a very high index of suspicion is required to reach the clinical diagnosis in a timely manner and institute appropriate surgical management. The derivation of the cyst, differential diagnosis, and mechanism of angle closure glaucoma are discussed.

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The paper presents the developed variants of enzyme immunoassay (EIA) using two M. Proton pump inhibitors (PPIs) are far more effective than H2 receptor antagonists (H2RAs) or prokinetics with regard to the speed of symptom relief.

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Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice. Agar gel immunological studies on additional fractions of gamma globulin in human serum The patient underwent neoadjuvant and adjuvant chemotherapy and below-the-knee amputation, and no local recurrence or metastasis was noted after 2 years of follow-up.

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Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background. Except single sampling sites and some tributaries, the pollution of the river Danube by As, Cr, Cu, Pb, Hg, Ni, and Zn can be regarded as rather low. First, we found that Raf activation alone was sufficient to partially reconstitute H-Ras(12V)-mediated morphological and growth transformation. This work reinforces the notion that gp96 is an endogenous DC activator and unveils that the context in which Ag is delivered to the immune system, in this case surface expression of gp96, has profound influence on immunity.

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Human Rights, Humanitarianism, and State Violence: Medical Documentation of Torture in Turkey. The Compass Strategy was implemented in the western metropolitan Melbourne and Barwon regions of Victoria, Australia. No clear association between lifetime ETS exposure from all sources and increased risk of lung cancer was found in the current study.

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Notably, this tissue degeneration can be efficiently counterbalanced by compensatory proliferation of wild-type cells. In prokaryotes, IscS is also involved in various metabolic functions, including thio-modification of tRNA. The swallowing process is commonly divided into oral, pharyngeal, and esophageal stages, according to the location of the bolus.

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In these cases, the recognition of an embolic event from infective endocarditis as the cause of the acute coronary syndrome allowed physicians to direct their interventions to optimize the appropriate care for each patient. Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus. Workplace bullying is common among trainee doctors and usually goes unreported. We performed a multi-institutional study to compare the long-term structural valve deterioration of isolated Hancock Standard versus Hancock II bioprostheses. The probabilities of death and progression to hepatocellular carcinoma, hepatic decompensation (hepatic encephalopathy, esophageal varices, ascites, or portal hypertension) or liver transplant were estimated over 1, 2, or 5 years by fibrosis stage (Metavir F0-F4) determined by biopsy at beginning of observation.

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(32)Pcolloid radiotherapy or endostatin anti-angiogenesis therapy were able to inhibit the growth of HCC cells in vivo, while the combination of (32)P and endostatin showed much better therapeutic effect in HCC treatment. Foreign bodies in the oral cavity of very young children are rare and difficult to diagnose.

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Application of the new insertion-deletion polymorphism kit for forensic identification and parentage testing on the Czech population. In this case- control study, the participants were interviewed by a child psychiatrist and the measures included: kiddie Schedule for Affective Disorder and Schizophrenia for school age children (K-SADS), Opium Treatment Index (OTI) and Global Assessment Functioning (GAF). In addition, we examine the relationship between OSM and other visual-cognitive phenomena, including object correspondence through occlusion, change blindness, metacontrast masking, backward masking, and visual short-term memory.

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Analysis of different stages of coeliac disease suggests that the epithelial distribution of tissue transglutaminase is gluten dependent. No data exist concerning three-dimensional bone augmentation using PDGF and a xenograft in humans. This might be one of the reasons for the incidence of stroke to higher in low-lying lands that it is in mountainous areas. Educational scheme for patients on home peritoneal dialysis in Spain For each patient, one to three biopsy cores were imaged with FFOCT immediately after sampling.

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In this view, I(f) inhibitors have been developed in the past, yet the only molecule to have reached the clinical development is ivabradine. Finally, we observed that Fao cells totally escaped the inhibitory action of a covalent inhibitor of chymotrypsin after having been exposed to insulin for 10 h. For EpoR, there is good evidence that the unliganded receptor is already a preformed dimer that is activated by a ligand-induced change in the receptor conformation. We evaluated the efficacy and safety of adding adefovir dipivoxil to lamivudine in 135 patients with chronic hepatitis B (CHB) and YMDD mutant HBV.

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Nursing in the acute stage following surgery of brain tumor--care at the neurosurgical intensive care unit We report that pMYCN is phosphorylated in vitro by purified casein kinase II (CK-II).

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albicans in scid mice, but nontheless, abrogation of NK cell activity is not associated with enhanced susceptibility to candidiasis induced by i.p. Telomerase is a ribonucleoprotein that extends the telomeric ends of the chromosomes to counterbalance the natural shortening due to incomplete DNA replication in eukaryotic cells.

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Incompletely replicated DNA apparently activates a regulatory mechanism that prevents activation of the mitotic inducer M-phase kinase by controlling the dephosphorylation of a critical tyrosine residue in the active site of the kinase. The patient was a 55-year-old man who had been on hemodialysis for 6 years for diabetic nephropathy.

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A prominent candidate for such a chelator is the Cys-rich protein thionein (apometallothionein) that is inducible by heavy metal loads, and by other environmental stimuli. The width of the edentulous space was much greater than the mesiodistal width of the lost tooth, impeding the construction of a conventional fixed partial denture.

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On TiCP Osseotite surfaces the osteoblastic cells conformed to the irregular terrain of the sustrate with focal adhesion sites only established on the relative topographical peaks separated for a longer distance than in the machined surface, and defined wide lamellopodia and long filopodia, with enhanced expression of stress fibers, forming large clear focal contacts with the rough surface. These results are comparable to those previously published for rat and gerbil, and further emphasize the possible contribution of sex differences in maternal stimulation, especially AGL, to the development of sexually dimorphic features of brain and behavioral development in different mammalian orders.

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Results of unrelated cord blood transplant in fanconi anemia patients: risk factor analysis for engraftment and survival. Dying in hospital: a study of incidence and factors related to hospital death using death certificate data. The sphenoid sinus types and the SO were evaluated three dimensionally. During the process of slaughter, the pH was found to show a decrease, whereas the concentrations of protein and blood increased. The strongest interactions were observed for compounds with well-established H-bonding potentials.

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Additional to caudal bupivacaine preemptive oral ibuprofen does not improve postoperative pain, nausea or vomiting, and resumption of normal activities in children after ambulatory pediatric urologic surgery. Biologic intoxication due to digitalis-like substance after ingestion of cooked toad soup. This paper quantifies these advantages and disadvantages, and evaluate the means by which the latter might be surmounted. Heparan sulphate proteoglycan (HSPG) is present in the glomerular basement membrane (GBM) and is thought to play a major role in the glomerular charge barrier.

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Diel and seasonal movement pattern of the dusky grouper Epinephelus marginatus inside a marine reserve. The E-cadherin/catenin complex is a calcium-dependent cell-cell adhesion molecule, whose function is critical to the integrity of the adherens junction and which plays a role in the establishment and maintenance of normal epithelial morphology and differentiation. Simultaneous analysis of spatio-temporal gene expression for cephamycin biosynthesis in Streptomyces clavuligerus. Exposure to PUVA induced an increase in p53 expression in non-lesional skin in 14/19 patients, putatively as a response to DNA damage caused by PUVA. The better lubricating property and antiwear capability of the ionogels compared to the EAN may be attributed to the structure characteristics and the good thixotropic properties.

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Measurements of the middle cerebral artery in digital subtraction angiography and MR angiography. However, first events in electron transport and whole needle photosynthesis are strongly affected by light and temperature conditions during the days before sampling. Therapy consisted of a 30 minute intravenous (IV) infusion on day i thraugh 5, every 2 weeks. We present the genetic analyses by both haplotype and direct RET proto-oncogene mutation analysis in seven Mediterranean MEN 2A families and have compared these results with biochemical screening tests and pathological examinations.

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This was a cross-sectional study using an online survey to evaluate the provision of nurse-led and delivered services within genitourinary medicine in the UK. Inoculation of murine bone marrow mesenchymal stem cells induces tumor necrosis in mouse with orthotopic hepatocellular carcinoma Dietary daidzein and genistein intakes were obtained from 7-day food diaries, completed by participants between 1993 and 1998 and calculated from an in-house food composition database.

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Establishment of FSH-responsive cell lines by transfection of pre-ovulatory human granulosa cells with mutated p53 (p53val135) and Ha-ras genes. Seven patients also had an anterior cruciate ligament (ACL) injury of which one was repaired 6 years after meniscal repair. The effect of risk factors is further magnified in urban areas through risk accumulation.As mother and child share their background, neonatal, and maternal adverse health outcome patterns coincide, resulting in similar inequalities and similar epidemiological trends. To report the first example of an abnormal magnetic resonance imaging (MRI) test in a patient with migraine and olfactory hallucinations and to provide additional evidence for a possible role of the temporal lobe in migraine. These epidemics have a strong association with the environment and efforts are being made to develop models to predict both their location and their incidence.

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There have been many other clinical trials of thrombolytic drugs beyond the 3-hour time window and neuroprotective drugs, but none of these trials have been positive. Interestingly, the 49K protein has a rather short half-life and seems to be proteolytically cleaved. We present a patient with a tibial metaphysis osteochondroma inducing popliteal artery compression that was relieved after resection. Whole cell lysate from growing cell cultures was treated with the broad phosphatase spectrum of CIP, resulting in a decrease in the molecular mass of RBM5.

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The early detection of chlamydial infections is very important because they may cause cervicitis, endometritis and salpingitis and because of that reason for sterility in women. Guidelines recommend storing tuberculin purified protein derivative (PPD) refrigerated.

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In this article the authors report an analysis and long term results of delayed/salvage radiation therapy administered to asymptomatic patients who had an elevated prostate specific antigen (PSA) level, many months to many years after radical prostatectomy. Brainstem auditory-evoked potentials (BAEP) were recorded between vertex and tragus in 22 guinea pigs, after destruction of the contralateral ear in order to produce monaural stimulation. This may obviate the use of complicated procedures and equations to perhaps needlessly apply a small correction factor to HFT data.

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The Census 2000 questions may not provide an accurate profile of disability in America. In addition, patients in HMOs report less satisfaction, less trust in physicians and lower ratings of physician visits. Decreased membrane fluidity in polymorphonuclear cells in psoriasis.

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Histological observation of the grafted tissue showed instead only a mild and not significant neutrophilic infiltration, equal in each group. Effect of reserpine on the process of mobilization of a glycogen depot in the myocardium during hypoxia The dramatic proneness to skin cancer of XP-V individuals highlights the importance of this DNA polymerase in cancer avoidance. Steered molecular dynamics simulations are performed to explore the unfolding and refolding processes of CLN025, a 10-residue beta-hairpin. Passive smoking, or environmental tobacco smoke (ETS), is a risk factor for lung cancer, cardiovascular disease, and childhood asthma, but a relationship with COPD has not been fully established.

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The major reasons for this are patient characteristics such as cardiovascular co-morbidity and high UF rates and a lack of understanding of the relation between RBV changes and blood pressure/cardiovascular stability. Anchorage-independent growth in soft agar was reduced for those cell lines expressing the E1AdelCR2 mutant, which lacks the entire conserved region 2 (CR2) sequences, or for cells expressing the E1AcR3Ex2 mutant, which contains CR3 plus exon 2 sequences. The mass responses were followed not only by MRI but also by FDG-PET, which was taken prior to treatment, and at one and six months after the treatment. This shift showed maximal expression when a high degree of pain was anticipated.

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Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2. Studies have suggested that neurotrophins may protect neurons from the toxic effects of HIV-associated proteins. Osteosynthesis in mandibular fractures with pins made of biocompatible polymers