Spiron is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spiron was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat a number of conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome. Off label uses of Spiron involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris. Spiron is also frequently used in medical gender transition. Spiron was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.
Other names for this medication:
Spironolactone,
Aldactone,
Aldactazide,
Aldactazine,
Aldazida,
Aldazide,
Aldozone,
Alexan,
Alizar,
Carpiaton,
Espirone,
Espironolactona,
Expal,
Kespirona,
Lanx,
Letonal,
Osiren,
Osyrol,
Practon,
Prilactone,
Spiractin,
Spiresis,
Spirix,
Spiroctan,
Spirolang,
Spirolon,
Spiron,
Spirono,
Spironolacton,
Spironolactona,
Spironolakton,
Spironolattone,
Spirotone,
Verospiron,
Xenalon,
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CPITN assessments in institutionalised elderly people in Kitakyushu, Japan. These include the mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. Plant diversity shapes microbe-rhizosphere effects on P mobilisation from organic matter in soil. Hence, the driving forces for the right-handed twist of beta-sheets must come blavin 5 mg precious moments principally from interactions between strands.
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