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Topina (Topiramate)

Topina is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Topina antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Functional analysis demonstrates that msh is essential for proper development of the tritocerebral neuromere and brain neuropile glia. A one-stage modification of the test of the migration inhibition is described, which permits stimultaneous study of the factor influencing in vitro migration of peripheral blood leukocytes and mouse spleen cells.

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Severe hearing loss was associated with younger age at admission. ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation. Judges were presented either pictures of the closed mouth sets or pictures of the open mouth sets and were asked to rate on a 10-point scale the chance that the child was shy, had few friends, belonged to a lower socioeconomic class, had problems with reading, writing, or arithmetic, had ever manifested thumb-sucking, and had difficulties breathing through the nose. In these complex aneurysms the complication rate is higher than in conventional stent-assisted coiling.

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Assessing bioavailability of complex chemical mixtures in contaminated soils: Progress made and research needs. Possible applications of SBH include physical mapping (ordering) of overlapping DNA clones, sequence checking, DNA fingerprinting comparisons of normal and disease-causing genes, and the identification of DNA fragments with particular sequence motifs in complementary DNA and genomic libraries. Autonomic changes and heart rate variability in children with neurocardiac syncope. When such minigenomes are coexpressed with RNP proteins in mammalian cells, the RNP proteins recognize them as authentic templates for replication and transcription, resulting in reporter activity reflecting these processes.

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There is not a single clinical picture of arthritis in patients with chronic HCV infection. Olfaction initiates with the interaction of odorants with specific receptors on the surface of olfactory sensory neurons in the nose. Beside the improvement of life quality and extension of life time the aim of IPPV is a reduction of the secondary effects of chronic hypoventilation in order to stabilize the symptoms.

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Role of Ser(289) in RARgamma and its homologous amino acid residue of RARalpha and RARbeta in the binding of retinoic acid. Autologous hamstring grafts are commonly used for knee reconstruction. leprae (the average transformation being higher than the average transformation of lymphocytes of tuberculoid leprosy patients). Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor. There was no notable difference in clinical performance of the FB and MB implants with the numbers available.

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The electrophysiological evaluation of Wolff-Parkinson-White syndrome (WPW) is recommended in children aged more than five years to detect a risk of life-threatening arrhythmia. The transient receptor potential ankyrin repeat 1 (TRPA1) channel is believed to be involved in many forms of acute and chronic hyperalgesia. Applications in both developed and developing countries are also described. The neurocutaneous syndromes are characterized by congenital dysplastic abnormalities involving the skin and nervous system.

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We have used the vtc1 mutant to provide a molecular signature for vitamin C deficiency in plants. An alternative combines intra-abdominal fixation of the gastroesophageal junction via a Hill gastropexy with a Nissen fundoplication to maintain length and avoid juxtaposing acid-secreting tissue against the diseased esophagus.

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Although an effective therapeutic regimen can generally be achieved with no exact knowledge of the arrhythmic mechanism or of the specific action of a given drug, future investigations hould augment existing information to yield a more rational means of treatment and prevention of arrhythmias as well as to aid in the development of new antiarrhythmic agents. This study compares the modulation of the startle response by conditions requiring response preparation, production, and inhibition during a cued continuous performance task (CPT) in children to the results of previous studies in adults and evaluates the modulation of the startle-elicited P300 under the same conditions. Downward movement of TCS and TCC occurred within a 10-cm soil depth.

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Gross margins for prescriptions dispensed in the month before and after the reimbursement change. Enalapril induced persistent hypotension and acute renal failure. During regimen 1 there was a marked rise in mean tmax from 3.3 h after dosing at 11.00 h to 9.3 h after dosing at 23.00 h (P less than 0.001). Flora analysis of riparian plant communities on the northern slope of Changbai Mountain After 2 years of training, the neural responses of the music training group were earlier than at pre-training, while the neural timing of students in the fitness training group was unchanged.

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Furthermore, a laparoscopic approach provides excellent visualization of the abdominal organs and enables high quality biopsies to be taken that are invariably more diagnostic than percutaneous needle biopsies. The serotonergic system has long been suspected in disorders that have symptoms of repetitive behaviors and resistance to change, including autism. Our data suggest that T-cells are able to modulate B7 expression on microglial cells in the brain independent of antigen presentation through TCR/MHC-II ligation but presumably by soluble mediators. The aged DNV and NMP groups were further divided into two subgroups, based on the period after RLN transection (10 or 20 weeks).

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The influence of lateral and supine position on bacterial colonization of endotracheal tube in neonates admitted to neonatal intensive care unit. We show that this mechanism involving cortactin phosphorylation, local pH increase, and cofilin activation regulates the dynamic cycles of invadopodium protrusion and retraction and is essential for cell invasion in 3D. The circadian variation of acute cardiovascular events may be discussed as an essential factor influencing the circadian variation of habitual daily activities in patients with cardiac disease. Failure of stavudine-lamivudine combination therapy in antiretroviral-naive patients with AZT-like HIV-1 resistance mutations. The biomechanical analysis was performed simulating a fall on the trochanter using a servo-hydraulic machine.

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topina meaning of name

The influence of faecal consistency and dry matter content on Fasciola hepatica egg-counts in cattle. In this study, we measured activity of two members of the Rho family of GTPases, Rac and RhoA, in the mushroom bodies of bees with different durations of foraging experience.

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Both methods are based on an analysis of the eigenvalues of the spatial covariance matrix corresponding to the individual multilead ECG. Double recurrence of otogenic abscess of the left cerebellar hemisphere Components of the conserved NDC80 complex are required for chromosome congression, and their disruption results in mitotic arrest accompanied by multiple spindle aberrations. The reported association of polymorphisms in the osteoprotegerin (OPG) gene with osteoporosis suggests that the OPG gene may also influence the genetic risk for periodontitis. Coexistence of X-linked recessive Emery-Dreifuss muscular dystrophy with inclusion body myositis-like morphology.

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Genetic studies in mice revealed that Che-1 is essential for preimplantation development and the establishment of embryonic gene expression. Explore the level and variation in feeding skill performance through the first post-term year and examine the contribution to performance of infant neonatal condition and rate of weight gain per day, maternal feeding behavior, and its interaction with neonatal condition. Combined magnetic resonance coronary artery imaging, myocardial perfusion and late gadolinium enhancement in patients with suspected coronary artery disease.

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Improvement of facial appearance and nocturnal breathing with geniotomy (sliding genioplasty): report of two cases. Comparisons of statistical tests were done with the Kruskal-Wallis test.

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The coating quality was confirmed by high resolution transmission electron microscopy, energy filtered transmission electron microscopy and electrochemical characterization. In this prospective study, optical biometry was performed twice in 79 patients: first by a qualified ophthalmic nurse and second by 1 of several health care assistants without formal nursing training. To review current evidence for the hypothesis that treatment with antipsychotic medications may be associated with increased risks for weight gain, insulin resistance, hyperglycemia, dyslipidemia, and type 2 diabetes mellitus (T2DM) and to examine the relation of adiposity to medical risk.

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Importance of the transportation of samples and means of isolation Comparison between CT and other modalities, however, lack validity unless the protocol for each procedure is optimized. Bisphosphonates have become the treatment of choice for tumor-induced hypercalcaemia and more recently they have been used alone or in combination with cytotoxic agents in the palliative treatment of patients with bone metastases. Main and interactive effects of emotion dysregulation and breath-holding duration in relation to panic-relevant fear and expectancies about anxiety-related sensations among adult daily smokers. This indicates the prophylactic potential of thiamine for lead-induced lipid peroxidation.

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Of these profiles, the Oncotype Dx and Mammaprint assays are the best validated and are commercially available. Thus, changes in MT mRNA turn-over rates may play an important role in regulating the accumulation of MT mRNA.

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Drug release studies were performed in media mimicking stomach and intestinal fluids. Transcranial Doppler ultrasonography is the most commonly used method of cerebrovascular blood flow velocity measurement, but it is subject to certain technical and anatomic limitations. Commonly used Bacteria-specific primers 8F and 27F paired with the universal primer 1492R amplify both eukaryotic and prokaryotic rRNA genes.

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xylostella were significantly heavier than pupae of pea-feeding P. In particular, it is shown how to construct parameterized families of solutions. However, the toremifene-o-quinone was shown to be considerably more reactive than the tamoxifen-o-quinone in terms of both kinetic data as well as the yield and type of deoxynucleoside adducts formed. Artificial organ treatment for multiple organ failure, acute renal failure, and sepsis: recent new trends.

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Subsequent nonsteroidal antiandrogen therapies were effective against prostate cancer relapse after hormonal therapy. Successful endovascular treatment of three fusiform cerebral aneurysms with the Pipeline Embolization Device in a patient with dilating HIV vasculopathy. Association between the apolipoprotein E4 and postoperative cognitive dysfunction in elderly patients undergoing intravenous anesthesia and inhalation anesthesia. We have previously reported that the level of leucine-rich alpha-2-glycoprotein (LRG) expression is specifically increased in cerebrospinal fluid (CSF) of idiopathic normal pressure hydrocephalus (INPH).

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The effects of variations in breast thickness, tumor depth, and tumor-to-background ratio were all simulated in this phantom model. The purpose of this study was to examine psychotropic medication utilization over the course of treatment for children and adolescents admitted to a large residential group-home facility for youth with emotional and behavioral disorders. Cardiovascular diseases are leading causes of mortality worldwide. Forensic chemical diagnosis of mushroom poisonings is a problem still to be solved.

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The reliance of perception on the number of displayed points and frames supports the idea that biological motion is perceived from a sequence of spatiotemporally sampled forms. HU of the renal papilla is significantly increased in SF in the affected and the non-affected kidneys when compared to the CG. Histologically, there was a dermal proliferation of spindle and epithelioid atypical melanocytic cells. In the current review, we will summarize stimuli influencing skeletal muscle stem cells activation, that is, growth factors which are secreted by muscle fibers, satellite cells, inflammatory cells, or released from basal lamina.

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Moreover, the exponential growth of known Y chromosomal lineages will require an automatic determination of the phylogenetic position of an individual based on whole genome SNP calling data and an up to date Y chromosomal tree. It had few adverse effects and gave considerable improvement in quality of life. For the PMS women, none of their cardiovascular measures differed across their cycle. The amino acid compositions of these surface antigens are also similar to the unusual composition of HIV proteins, which are deficient in proline and rich in lysine and other polar residues encoded by A-rich codons. It is classified into three levels as lower, middle and upper according to color and welding degree.

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Identification of unique synergistic drug combinations associated with downexpression of survivin in a preclinical breast cancer model system. O-(beta-hydroxyethyl)-rutoside (Venoruton) fails to block histamine or bradykinin-induced edema formation in the canine forelimb perfused at constant arterial inflow. To examine the effects of POM3 plus atorvastatin versus placebo plus atorvastatin on lipoprotein particle concentrations and sizes, apolipoprotein (Apo) CIII, and lipoprotein-associated phospholipase A(2) mass in subjects with mixed dyslipidemia. This is partially due to ethical issues limiting the access to research material. The role of apelin in pathogenesis of cardiovascular diseases and metabolic disorders

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All the available ophthalmic antibiotics have strengths and weaknesses. Transgenic mice that express two nonsecretory forms of mutated bGHs were found to lack the enhanced mouse growth phenotype in spite of elevated levels of serum bGH. Between birth and 3 yr, the distribution and relative number of immunoreactive nerves shown by both the general neuronal markers and specific antisera did not change. Four important phenotypical determinants were tested: sorbosa, sorbitol, enterohemolysin and 0157:H7 serology, in order to select those strains from enterohemorrhagic or Shiga toxin-producing category.

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This report reviews existing methods for detection of parent-of-origin effects, showing that each can be invalid under certain scenarios. Biopsy specimens were processed by standard histopathological and immunohistochemical techniques and effective doses were individually calculated.

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Although the importance of conformational changes within isolated I domains in regulating ligand binding has been reported, the relationship between metal ion binding affinity and ligand binding affinity has not been elucidated. Paediatric epiglottitis is a serious, potentially life-threatening condition. External trigeminal nerve stimulation (eTNS) is a non-invasive neurostimulation treatment for drug refractory epilepsy. Nevertheless, alkylphospholipids change the detergent-solubility of zonula occludens-protein and occludin.

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Men with symptoms of PE often report a significant impact of the condition on their lives, experiencing personal distress and interpersonal difficulty related to their condition. Finally, some recent developments are described that demonstrate the potential for further growth of Biochemical Systems Theory and the underlying Power-Law Formalism on which it is based. Therefore, suppression of lymphatic metastasis provides an improvement in survival time in lung cancer patients.

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Charge transfer between graphane and the molecules and ions have been found to be an important factor in determining the binding strength of the complexes. The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro. This article reviews several clinical and experimental studies dealing with these questions. Thirty-one patients with intractable complex partial seizures associated with either left temporal lobe epilepsy (LTLE) or right temporal lobe epilepsy (RTLE) underwent assessment of memory for tonal patterns during a baseline phase and right and left cerebral hemisphere anaesthesia during the IAP.

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This is considered a metachronous or step-wise progression of the malignant process. In the polyglutamine disease spinocerebellar ataxia type 7 (SCA7), Purkinje cells undergo non-cell-autonomous degeneration in transgenic mice. This class of enzyme is therefore implicated in the dermo-epidermal separation which is associated with blistering in humans following exposure to HD. For the various donors, with different activities of these antioxidant systems before irradiation, TBARS correlated positively with SOD activity and negatively with Cat activity, whereas no correlation with GSH level or GSHPx activity was found.

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If the injected collagen is replaced with a contracted scar, however, urethral coaptation may not persist. We concluded that depolarization at low pH was not due to rotational diffusion but mainly due to energy migration between adjacent tryptophan residues. Inevitably space is lacking for us to cite all the progress in medical oncology. Using the Urolase right-angle laser fiber, this study suggests that 40 watts power setting and 90 seconds continuous application time with a Neodymium:YAG laser source represent optimal treatment parameters to maximize prostatic tissue coagulation. We found that ST8Sia II/STX is modified by six Asn-linked oligosaccharides and that polysialic acid is distributed among the oligosaccharides modifying Asn 89, 219, and 234.

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Influence of lateral destabilization on compensatory stepping responses. The solubility of the man-made mineral fibers also correlated with the half-life of clearance in an in-vivo study. Recent studies however provide strong clues to a second messenger role for sphingosine and identification of effectors reveal a possible mechanism involved in sphingosine-mediated cell death. Rabies should form part of a differential diagnosis for any patient presenting with a history of travel to a rabies endemic country and displaying an undiagnosed encephalopathy.

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This study was done to evaluate the feasibility and outcome of NIMV in tertiary care centres. The Q-switched ruby laser (wave-length 694 nm, pulse duration 25 ns or 40 ns) causes selective damage to natural or artificial pigment. Reactivation of Mycobacterium tuberculosis (TB) is a significant problem with all available tumour necrosis factor (TNF) antagonists when used to treat rheumatoid arthritis esoral 40 mg prix (RA), psoriatic arthritis, psoriasis and other inflammatory diseases. Usually chickenpox is a self-limiting and relatively mild disease of childhood, although it is frequently more severe with significant complications, and less often, is responsible for case fatalities.

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Group II: Three-dimensional conformal radiotherapy treatment--357 patients treated with more than 74 Gy matched on stage and grade to 357 patients treated with less than 74 Gy. The literature review demonstrates that spastic tetraparesis, secondary to cervical cord compression, is the most common presentation of this subgroup of patients. Tracing the evolutionary history of Drosophila regulatory regions with models that identify transcription factor binding sites. Using the CW-Doppler USCOM a different deroxat 10 mg grossesse 5 hemodynamic response to epirubicin vs. However, recombinant HDACm, injected into the cytoplasm of oocytes, not only is translocated to the nucleus, but also is free to interact with the endogenous chromatin.

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Future research should test potential mechanisms that might underlie this association. Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites. The inability of the anti-NGF antibody to inhibit completely the granuloma-induced neurite outgrowth in the bioassay signifies that NGF is not the severe allopurinol gout side effects only neurotrophic factor present in these granulomas. CGM use is associated with a significant reduction of HbA1c in adults but not in children.

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Experimental allergic encephalomyelitis: characterization of T lymphocytes that bind myelin basic protein and synapsin. Apparent diffusion coefficient (ADC) was markedly suppressed in all regions examined except for cerebral cortex. To anticonvulsant hypersensitivity syndrome lamotrigine lamictal side determine the stability of amlodipine besylate in two liquid dosage forms under refrigeration and at room temperature.

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This revealed that the internal lamin structures consisted of small foci and omeprazole magnesium overdose in kids fibres proliferating throughout the nucleus. Introduction of strict glycemic control has increased the risk for hypoglycemia in the intensive care unit.

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The correlation between genome size and AT content, with respect to the C. However, prolonged exposure to phorbol esters, or growth in serum, results in localization of CalDAG-GEFI to the cell membrane and restoration of Ras exchange activity. Using isolated rat renal proximal tubules in suspension, the cellular events preceding OA- or OSN-induced cytotoxicity were nombre generico augmentin 500 investigated. Surgical site infection was defined according to Centers for Disease Control and Prevention guidelines.

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A portable apparatus for objective and subjective determination of visual acuity In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a quetiapine 25 milligram tablets with keyboards joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes. The epidemiology of insulin-dependent diabetes mellitus (IDDM) was evaluated in a predominantly black population in the U.S. Comparative study of neonates weighing under 1000 and 1000-1250 g at birth.

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Motility, acrosome integrity and fertility of frozen ram spermatozoa treated with caffeine, pentoxifylline, cAMP, 2-deoxyadenosine and kallikrein. Highly efficient CO2 sorbents: development of synthetic, calcium-rich dolomites. Human active renin was quantified by immunoradiometric assay which could detect only the human active renin but not the inactive human renin or dog renin. The use of iPads can greatly impact nursing education which not only engages the staff, but provides an environment that is conducive to learning, is cost effective, and fun. Areas of brain from rats were homogenized and purified with SepPak procelac abiotic vs biotic C-18 cartridges.