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Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation. The bacterium was inoculated into intermediate-scale field lysimeters and population dynamics were monitored with time. This potentiates the cytotoxic activity of yatakemycin and its analogues overcoming limitations typically observed with more traditional compounds in the series (CC-1065, duocarmycins). There is a paradox in that some types of nanoparticles (a generic term for particles less than approximately 100 nm in diameter) are used in nanomedicine for imaging and therapy, whereas other types of nanoparticles produced by combustion are thought by many scientists to be responsible for the adverse health effects of air pollution. This condition is influenced by daily habits and occupational duties.
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Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols. To determine the regulating role of interleukin-1 alpha and beta (IL-1 alpha, beta) and tumor necrosis factor alpha (TNF-alpha) on inhibition of proteoglycan synthesis and proteoglycan degradation in early immune complex arthritis (ICA) in the mouse. We observed that a treatment with the genotoxic stress inducer camptothecin for 6 h favored the production of the H-ras NMD-target transcript degraded in the cytosol by the NMD process.
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