Envarsus is a macrolide isolated from the fungus Streptomyces tsukubaensis. Envarsus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Envarsus possesses similar immunosuppressive properties to cyclosporine, but is more potent. Check for active clinical trials using this agent.
Other names for this medication:
Tacrolimus,
Advagraf,
Envarsus,
Prograf,
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