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To enable this analysis, we introduce a new method, stratified LD score regression, for partitioning heritability from GWAS summary statistics while accounting for linked markers. Oxygen-induced retinopathy was induced by subjecting mice postnatal day (P)7 to hyperoxic conditions (5 days) followed by normoxic conditions (relative hypoxia).

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This is complicated by the fact that the majority ofSLTs in South Africa are English or Afrikaans speakers, while the majority of the population have a home language other than English/Afrikaans. Modeling of gene regulatory networks with hybrid differential evolution and particle swarm optimization.

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In this paper, we present three alternatives to learn a Probabilistic Latent Semantic Analysis model (PLSA) for annotated images, and evaluate their respective performance for automatic image indexing. Ocular hypertension following Nd:YAG laser capsulotomy: a potentially blinding complication. Topical corticosteroid in normal patients and glaucoma suspects. Prediction of fungicidal activities of rice blast disease based on least-squares support vector machines and project pursuit regression. Seasonal variation in 25-OH vitamin D in plasma of Hong Kong Chinese.

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The characterization of biotherapeutics represents a major analytical challenge. The blood coagulation process plays an important role in fibrin formation in thrombi. With all study regimens, the provision of prompt and reasonably effective facility-based treatment was associated with good outcomes in long-term health measures.

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It was concluded that aggression in general is characterized by a delayed norepinephrine stress response and that an association with high epinephrine is typical for aggressiveness in hypertensives. This study measures the impact of HMO-induced price competition on the rate of inflation in average cost per admission for 298 private, non-HMO hospitals between 1982 and 1988.

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In the 2005 period, 47 donors and 124 patients were entered by nine centers, and six hemiliver allocations for three SLT A/A procedures were performed. The influence of psychosocial stress on the risk of spontaneous abortion is unclear.

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Therefore, we have here developed a procedure for describing and classifying virus particle forms in electron micrographs, based on determination of the invariant characteristics of the projection of a given virus structure. To study the regulation of human apolipoprotein AI(h-apo AI) gene expression and its role in high density lipoprotein (HDL) metabolism.

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In order to search for a possible molecular target of such compounds, their role as Taq polymerase I inhibitors was studied. In 63 schistosomiasis epidemic counties of Hubei Province, there were 3 types of endemic situation, that was endemic controlled, transmission controlled, and transmission interrupted. The objective of this study is to review and synthesize all the available evidence on treatment options for PCOS among adolescent women. Nowadays scientists have to face a new challenge that corresponds to the elucidation of the function(s) of the thousands of genes uncovered by sequencing.

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Evaluation of in vitro antioxidant properties of methanol and aqueous extracts of Parkinsonia aculeata L. Although residues A10 and A12 are stacked in the helix, the phosphodiester backbones are distorted. To evaluate the health outcomes and economics associated with the current guidance relating to the prevention of falls in the elderly through vitamin D supplementation. The European Working Time Regulations (EWTR) have been criticized for its purported negative impact on the training of junior doctors.

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Propofol and midazolam are commonly used sedatives during regional anesthesia in adults. Monitoring in real time the cytotoxic effect of Clostridium difficile upon the intestinal epithelial cell line HT29. PVP can serve as a surface stabilizer, growth modifier, nanoparticle dispersant, and reducing agent. Troglitazone had growth inhibitory and differentiation induction effects on the pancreatic cancer cell lines through the upregulation of p21 expression, suggesting that ligand activation of PPAR gamma is a new molecular target for effective therapy against pancreatic cancer. The technique increased vertical dimension about 4 mm on average and allowed placement of longer endosseous implants.

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Such assays have been applied to erythropoiesis and have demonstrated classes of precursors which differ significantly in their growth potential, physical characteristics, and sensitivity to the hormone, erythropoietin. Appropriate utilization of hospital beds in internal medicine: evaluation in a tertiary care hospital. Lattice dynamics and origin of ferroelectricity in BaTiO3: Linearized-augmented-plane-wave total-energy calculations. Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy.

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Enhancement of mucus accumulation in a human gastric scirrhous carcinoma cell line (KATO-III) by fibroblast-tumor cell interaction. The essential metabolites are capable of maintaining a steady flux-sum even against severe perturbation by actively redistributing the relevant fluxes. Our results pave the way to a better understanding of plant-microbe interactions and highlight future applications for a more sustainable agriculture.

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In this study, we evaluated the effects of N-glycosylation on Cluc properties by creating site-directed mutagenic modifications at the consensus sequence for N-glycosylation (Asn-X-Ser/Thr). We found that the polyembryonic parasitoid maintains and enhances the host immune system, whereas the other parasitoid strongly suppresses the immune system.

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The aim of this study was to determine difference in timing to postoperative chemotherapy for minimally invasive resection (MIR) vs. Data derives from a series of in-depth interviews and a locally informed survey. Lactate added-value assessment is dependent upon the performance of the underlying predictive model and should incorporate risk reclassification and net benefit measures.

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Conformations of 3-methylpurine nucleosides: implications on the structure of DNA duplexes. Cervical ROM was measured in the 3 planes with the Zebris CMS 70P ultrasound-based motion analysis system. However, this case portrays the dramatic electrocardiographic appearance of acute myocardial ischemia in a boy with biopsy-proven myocarditis who had only mild chest pain.

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To assess the ease on insertion, patient tolerance, undesirable side-effects, degree of encrustation and duration of upper tract decompression with a new thermo-expandable shape memory alloy ureteric stent. A unified model for T cell antigen recognition and thymic selection of the T cell repertoire. The patient was a 16-year-old girl who presented with loss of vision as the major clinical feature. Characteristics of the binding of thioflavin S to tau paired helical filaments.

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Pre-clinical evaluation of PLGA-modified NP distribution into hypo-vascularized tumor tissue may benefit from considering tissue morphology in addition to cancer type. Indeed, microarray and real-time PCR experiments showed that neither IFNbeta nor IFNbeta-dependent genes (including CXCL10) are inducible in LPS-treated neutrophils, in contrast to monocytes.

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adolescents aged 12-17 years meet the 2008 Guidelines, and whether demographic and BMI variables influence that prevalence. The extent of inhibition of adenylate cyclase by ANF varied from tissue to tissue. The origin recognition complex (ORC) was initially discovered in budding yeast extracts as a protein complex that binds with high affinity to autonomously replicating sequences in an ATP-dependent manner.

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Black race, lower BMI, lower serum triglyceride levels, and longer QRS duration were independently associated with maintenance of ER over time. LTP patients named significantly fewer melodies than BDC and NC participants.

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Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli. It was observed that xylene caused an increase of lipid peroxidation measured as a MDA level in all used concentrations, but gasoline only in very high doses. These findings make serotonin both friend and foe for the liver. Solar forcing of regional climate change during the Maunder Minimum. This article summarizes recent data on structure and function of the hepadnaviral P-protein and discusses its important role in the early steps of nucleocapsid assembly.

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Although rare, clinicians should be aware of this potential problem when prescribing extended-release medications to patients at risk, and should consider this possible etiology when refractory epigastric pain and weight loss occur. In acute myelogenous leukemia (AML) and adult T-cell leukemia, it has been demonstrated that the transcription factor LIL-STAT is constitutively activated. To gain insights into the roles of HOXA10 in the primate endometrium, its expression was studied in the endometria of bonnet monkey (Macaca radiata) in the receptive phase and also in the endometria of monkeys treated with antiprogestin onapristone (ZK98.299) or in conception cycle where the presence of preimplantation stage blastocyst was verified. Pregnancy outcomes after kidney transplantation-immunosuppressive therapy comparison. Although links between diet and exercise and chronic disease risks have been well documented, more needs to be known about motivations for behavioral change and perceived benefits as assessed using quality-of-life measures.

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We found that the expression of mBax induced specific cell death in the silk gland, fat body and sensory cells. In the nucleolus, labelling is particularly concentrated over the perinucleolar chromatin and over its intranucleolar invaginations, which penetrate the nucleolar body and often terminate at the fibrillar centres. A variety of six-membered-ring annulated 2H-indazoles and 1,2,3- and 1,2,4-triazoles were synthesized in good to excellent yields from the corresponding bromoethyl azoles and aryl iodides.

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Pregnancy-induced changes to lymphocyte-endothelial cell interactions were documented using adhesion of human lymphocytes to frozen mouse tissue sections under shear. Dispersion of repolarization, myocardial iso-source maps, and the electrocardiographic T and U waves. Critically, this study confirms that females appear to occupy more central positions than males in mandrill groups. These results suggest that the intravenous administration of PDE3 inhibitors exhibits a bronchodilatory effect. A case of bilateral synchronous renal cell carcinomas with metastases to the regional lymph nodes and later to the thyroid gland was treated with aggressive surgical extirpation and adjuvant gamma interferon.

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The transgenes could not influence the original biological properties of hMSCs. The stimulus-specific time course and topographic dynamics of cortical oscillatory activity indicate that the brain rapidly dissociates spatial coherence and meaning revealed through biological movement. The dopamine-mediated activation of both EGFP-D2 isoforms generated a robust inhibition of adenylyl cyclase type 5 in intact cells.

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The second group (milk group) was established by nine lambs that received milk of these goats. Children homozygous or heterozygous for the GHRd3 allele showed a significantly higher rate of postnatal catch-up, compared with those homozygous for the full-length allele. These results suggest that elderly patients with NIDDM have impaired L-arginine/nitric oxide (NO) pathways and the possibility of capillary rarefaction.

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Surgical treatment is necessary in patients with neurological deficit, spinal instability or drug resistance. To determine the effect of central corneal thickness and radius of the corneal curvature on intraocular pressure (IOP) measurements using the Tono-Pen and a noncontact tonometer in healthy Turkish schoolchildren.

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Anthropometric indicators of nutritional status: implications for fitness, activity, and health in school-age children and adolescents from Maputo, Mozambique. Spontaneous duodenal-colonic fistula in a patient with ulcer of the duodenum This is a rare report of serotonin syndrome induced by mirtazapine monotherapy. Twelve infants less than 12 months of age recovering from respiratory failure of variable etiology. Anatomical observations on a range of fossil and living marine and freshwater mammals are presented, including sirenians (manatees and dugongs), cetaceans (both baleen whales and toothed whales, including dolphins and porpoises), pinnipeds (seals, sea lions, and walruses), the sea otter, and the pygmy hippopotamus.

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Scorpions ARMS method is quicker, more sensitive and accurate in detecting the EGFR gene mutations and should provide important therapeutic and prognostic information to the clinicians. Studies of nonrenal cells have suggested that the functional activity of alpha6beta1 integrin is regulated by protein kinase C (PKC) activity.

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To determine the results of surgical treatment in patients with drug-resistant epilepsy, referred to the Dutch Epilepsy Surgery Program, who were treated in the University Medical Centre Utrecht, the Netherlands, in the period January 1973-December 1998. A spectrophotometer was used to measure the color of porcelain facings of the veneer crowns and the porcelain controls. People living in hilly residential areas in metropolitan Perth have less diabetes: spurious association or important environmental determinant? An anatomical descriptive study was performed on 10 cadaveric knees (ages 49-67 years).

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Second, the new approach enabled the quantifications of the degree of conservation in reported B or T cell epitopes. The diagnosis of alveolar hemorrhage is assisted by the presence of hemosiderin-laden macrophages (HLMs) in the BAL fluid or lung tissue.

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Biological insights into the expression of translation initiation factors from recombinant CHOK1SV cell lines and their relationship to enhanced productivity. To determine the difference between the predicted and postoperative refraction in eyes with silicone oil that had extracapsular cataract extraction (ECCE), and intraocular lens (IOL) implantation. In the case of graft copolymers, the stability of polymer-DNA complexes and transfection efficiency were affected by the graft length and amount of PEG side chain. Conversely, BAP1 is essential for maintaining ASXL2, but not ASXL1, protein stability. Cathepsin L of Triatoma brasiliensis (Reduviidae, Triatominae): sequence characterization, expression pattern and zymography.