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Endocrine factors influencing radiation injury to central nervous tissue. Comparison of the growth curves of cancer cells and cancer stem cells.

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Palliative treatment of bone metastasis is presented from an orthopedic point of view. This approach cannot replace the holistic and multidisciplinary approach of cardiac rehabilitation. Human serum albumin is a critical plasma protein produced by the liver with a number of accepted clinical indications in chronic liver disease including management of circulatory and renal dysfunction in patients with ascites. Here, we show that transcription factor PLZF can be SUMO modified at lysine residue 242, 387 and 396. An algorithm is described that projects between two sets of constrained scattering matrices.

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The levels of cardiovascular risk factors vary in different segments of a population. Moreover, the recent demonstration that UTX associates with the H3K4me3 histone methyltransferase MLL2 (ref. Fluorescence-Based Approaches for Quantitative Assessment of Protein Carbonylation, Protein Disulfides, and Protein Conformation in Biological Tissues. The involvement of salivary gland in diabetes mellitus has been suggested based on salivary flow rate and compositional alterations.

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The aim of the study was to compare clinical and radiographic outcomes of opening-wedge high tibial osteotomy (HTO) augmented with either xenograft or tricalcium phosphate spacer for the management of medial compartment osteoarthritis (OA) with genu varum. In a postmortem expression analysis of 33 individuals affected with schizophrenia and 30 unaffected control subjects, we showed that the SNAP25b/SNAP25a ratio was increased in schizophrenic patients carrying the rs6039769 at-risk allele. Flow cytometric analysis revealed that cultured carcinoma cells showed a cell cycle arrest at the G1-S transition after treatment with 10 microM D-Trp6-LHRH for 36 h.

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Model studies on peptides have shown that imide formation can also lead to peptide bond cleavage (Geiger, T., and Clarke, S. Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation. The function, protein level, and acetylation of p53 are downregulated by mdm2, which in its turn is inhibited by the p14(ARF) tumor suppressor. Nowadays, stress is defined as a real or interpreted threat to the physiological or psychological integrity of an individual, which results in a physiological and/or behavioral response.

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Vancomycin inhibited all strains at MICs of 0.25 to 0.5 micrograms/ml. Development of next-generation respiratory virus vaccines through targeted modifications to viral immunomodulatory genes. Comparison of the rates of exchange of lead in the blood of newly born infants and their mothers with lead from their current environment.

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Many microbial pathogens evolved to circumvent the attack of neutrophils, which are essential effector cells of the innate immune system. The available evidence does not appear sufficient to condemn ethylene oxide as a human mutagen at currently acceptable exposure levels. In this work we report on the preparation, characterization, and properties of a thermally treated lignin-derived, phenolic-rich fraction (PRF) of wood pyrolysis bio-oil obtained by ethyl acetate extraction. Reducing racial bias among health care providers: lessons from social-cognitive psychology. We included 37 RCTs evaluating 49 independent HIV risk reduction interventions with 10,190 participants.

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We identified spike genes in multiple myeloma cells of patients with newly-diagnosed myeloma and investigated their prognostic value. An inbred prematurely aging rat strain (OXYS) is characterized by high sensitivity to oxidative stress, lipid peroxidation, protein oxidation, DNA rearrangements, and pathological conditions paralleling several human degenerative diseases including learning and memory deterioration. Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4. We found both COX-1 and COX-2 to be constitutively expressed in all organs tested, i.e., brain, heart, liver, kidney, spleen and intestine.

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Visceral and renal tissue oxygenation during supraceliac aortic crossclamping and left heart bypass with selective organ perfusion. Exposure to exogenous elements like arsenic (As) may influence thyroid enzymes, thyroid-stimulating hormone (TSH), and the two principal thyroid hormones, free thyroxine (FT4) and free triiodothyronine (FT3), but little is known about how this is related to organic arsenicals, the main form in seafood. This study analysed genetic relatedness of 54 cultivars derived from nine species using amplified fragment length polymorphism (AFLP) markers. Back pain after vertebral augmentation may not be due to a failed procedure but rather to an old or a new pain generator, such as an irritated sacroiliac or lumbar facet joint.

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In addition, we show that erythropoietin, which is also required for erythroid cell survival, cooperates with GATA-1 to stimulate bcl-xL gene expression and to maintain erythroid cell viability during terminal maturation. Recent evidence shows that these proteins can associate with membrane lipids in special ways. This reduction was detected postnatally after normal migration of GnRH-1 neurons within nasal regions had occurred. Index finger motor imagery EEG pattern recognition in BCI applications using dictionary cleaned sparse representation-based classification for healthy people.

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Two experienced interventional neuroradiologists independently assessed the images and then reached consensus. Short-term effects of Org OD 14 and 17 beta-oestradiol on bone and lipid metabolism in early post-menopausal women. Maternal nutritional status (as measured by height, weight and BMI) in Bangladesh: trends and socio-economic association over the period 1996 to 2007. Eligible studies compare a screened population versus a non-screened population. Although the exact mechanisms of this change are unknown, we postulate that the lower maternal aldosterone levels and reduced levels of vasodilator substances, such as prostacyclin and kallikrein, may have a causal role.

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Site-specific and doping-dependent electronic structure of YBa2Cu3Ox probed by O 1s and Cu 2p x-ray-absorption spectroscopy. Change in the duration of the systole in changes of body position Considerable evidence now exists that cyclosporin (CyA) has a stimulatory effect on hair growth. There was no correlation between the occlusion and segmental stenosis, nor was there any correlation between dysfunction of the RWM of the RV and the posterior wall of the left ventricle (LVPW).

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The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile. Morbidity after pelvic exenteration for gynecological malignancies: a retrospective multicentric study of 230 patients. Phosphorylation of p68 by Cdk2-cyclin A greatly reduced its inhibitory effect.

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In control cells the AcCho-induced currents decayed slowly even in the continuous presence of AcCho. Determination of the ED95 for intrathecal plain bupivacaine combined with fentanyl in active labor. Differentially methylated fetal alleles were detected in maternal plasma by direct sequencing and a primer-extension assay.

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MDCT facilitates multiphasic contrast-enhanced study for a wide range of body scanning in a single examination, as well as providing flexibility of multidirectional reconstruction and high-quality three-dimensional imaging. A randomized, double-blind, parallel, placebo-controlled, 13-week clinical trial with follow-up of patients in an open trial of methotrexate at the conclusion of the double-blind study. Bionanotechnology is exploiting the rich structural knowledge now available on DNA and DNA-protein interactions to construct nucleoprotein-based devices that have the potential not only to contribute to our understanding of the structure and function of the proteins and nucleic acids involved but also to new approaches to problems in medicine. Cellular division follows a predictable 12-18 hour cycle resulting in two to sixteen cell preembryos over the first several days. Prevention of sugar-induced cataractogenesis in rats by butylated hydroxytoluene.

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The design objective was to eliminate manual handling of hematology data in order to enhance the reporting effectiveness of a computer-supported clinical pathology laboratory. Lessons from the organization of a proficiency testing program in food microbiology by interlaboratory comparison: analytical methods in use, impact of methods on bacterial counts and measurement uncertainty of bacterial counts.

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Randomized controlled study of leucomax (recombinant human granulocyte-macrophage colony stimulating factor, rhGM-CSF) in the treatment of cancer chemotherapy-induced leucopenia Women but not men showed an age related decline in FEV1 and FVC. Because of the serologic cross-reactivity of B gibsoni and B canis in the immunofluorescent antibody assay for IgG antibodies against these organisms, polymerase chain reaction amplification of parasite DNA was required to identify the infecting Babesia sp.

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All the patients underwent total hip arthroplasty with bone grafting or titanium cage for bone defect of the acetabulum. Despite the growing interest in and awareness of aesthetic surgeons for BDD, diagnosing BDD during a preoperative consultation remains challenging. Uterine fluid was collected 30, 60, 120 or 240 minutes later and tested for its effect on the in vitro morphology and chemotaxis of equine neutrophils by two independent methods. While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7.

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Magnetic resonance (MR) imaging, with its unique ability to noninvasively image and characterize soft tissue, has shown promise in assessment of cartilage integrity. All questionnaires and tests were performed before the CI surgery and at 6 and 12 months after CI activation.

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Once all tumor is macroscopically removed, no advantage could be demonstrated by more extensive surgical resection or current adjuvant therapy. In diabetes, renal RAS components are dysregulated, potentially increasing renal RAS effects.

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Upper gastrointestinal (GI) endoscopy has become a routine procedure in pediatrics. Charge separation in a reaction center incorporating bacteriochlorophyll for photoactive bacteriopheophytin. This is the first systematic study using quantitative real-time PCR to analyze and compare the expression profiles for critical members of the epidermal growth factor (EGF), transforming growth factor beta (TGFbeta), and vascular endothelial growth factor (VEGF) families in developing rat lungs.

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The inner sense of time: how the brain creates a representation of duration. Never before has the professional nurse been counted on for so much, and future expectations of the nurse continue to grow.

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Clinicoradiological considerations on the osseous metastases of germinal tumors of the testis The three volumetric irradiation indices are formulated with respect to a well-defined target volume. A system with a basic configuration (one extraction robot plus two real-time 96-well thermocyclers) operated by two persons could account for about 360 samples in 5 hr. To describe a case of Pseudomonas aeruginosa septicemia complicated by orbital cellulitis, panophthalmitis, and ecthyma gangrenosum.

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The deduced protein was identified as a bacterial formate/nitrite transporter (FocA) homolog and the gene was named EgFth. Changes in ECL cell density roughly paralleled changes in oxyntic mucosal histidine carboxylase activity and histamine concentration. Glycosylated haemoglobin in blood (HbAlc) values were also monitored. Gaze was therefore automatically primed to grasp-affordances though the task required evaluating tool-object context. Piezocision allows for rapid correction of severe malocclusions without the drawbacks of traumatic conventional corticotomy procedures.

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Facilitation and attenuation of social recognition in rats by different oxytocin-related peptides. Postoperatively, the patients were evaluated using a modified University of California Los Angeles (UCLA) rating system. H2O2-induced higher order chromatin degradation: a novel mechanism of oxidative genotoxicity.

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Fructose-1,6-diphosphate reduces acute ECG changes due to doxorubicin in isolated rat heart. Surgical and MR imaging findings in 50 patients with differentiated thyroid carcinoma (43 primary, 7 recurrent lesions) were retrospectively reviewed. Neuroendocrine secretory protein 55 (NESP55) is a recently characterized secretory protein localized to large dense-core vesicles resembling the class of chromogranins. The most prevalent diagnoses were attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, oppositional defiant disorder, and pervasive developmental disorder. Male C57BL/6N mice exhibited a robust fear response 24h after contextual and cued fear conditioning.

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From the gold standards of ultrasound, magnetic resonance (MR), and computed tomography (CT) to new and combined technologies, medical imaging is yielding extreme close-up views of the fine details of tissues and revealing the dynamics of cellular and molecular biology, often in real time. The authors report an extremely rare case of a patient with acromegaly who had unilateral enlargement of an atlas facet resulting in cord compression and progressive quadriparesis. Washout behavior of lepuridin as an anticoagulant in machine autotransfusion

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However, subjects reported that they were more comfortable using the transdermal patch particularly due to the once-a-day application and lesser frequency of systemic adverse effects. Dual signaling functions of the hybrid sensor kinase RpfC of Xanthomonas campestris involve either phosphorelay or receiver domain-protein interaction. The aim of the present study was to examine possible inequalities between young adult women and men in a combined assessment of positive health and health-related performance.

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The impact of standardized order sets and intensive clinical case management on outcomes in community-acquired pneumonia. Lack of training may contribute to reticence in engaging with their care. Draft Genome Sequences of Two Virulent Serotypes of Avian Pasteurella multocida.

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However, the effect of GSPE on UV irradiation is as yet unknown. In most cases the symptoms resolved within six months of fracture union but in four patients they were still present at one year and two of these had not returned to work. In addition, special attention is needed for the detection of adverse drug reactions resulting from possible drug-drug interactions.

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Observations on the pathology of bilharziasis and other parasitic infestations of Hippopotamus amphibius Linnaeus, 1758, from the Kruger National Park. Systolic hypertension is associated with increased cardiovascular morbidity and mortality.

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On the role of oxygen in fabricating microfluidic channels with ultraviolet curable materials. The effect of prolil-glycil-proline (PGP) peptide and PGP-rich substances on haemostatic parameters of rat blood. acnes can be isolated from sterile biopsied sarcoid lymph nodes of non-Japanese patients and supports the belief that there is an etiologic link between P. The identification of the mAbs against this S1 domain was performed using indirect enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence assay (IFA) and Western blotting, respectively.

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For each patient, clinical and physiologic parameters were investigated, and we performed immunohistochemical staining for p-Smad2/3 and TbetaRII, and genotyping of the TGF-beta1 codon 10 polymorphism. Continuous monitoring included intra-arterial blood pressure, pulse rate and ECG tracing.

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Lower extremity edema is an almost universal finding in late pregnancy, occurring secondary to increased venous pressure in the legs, obstruction of lymphatic flow, and reduced plasma colloid osmotic pressure.(1) Varney describes gestational edema as the development of an excessive accumulation of fluid in the tissues without coexisting hypertension or proteinuria.(2) Midwives are familiar with this common condition in an otherwise uncomplicated pregnancy and are comfortable reassuring clients that lower extremity edema is non-pathologic. The method can simplify the circuit and bring down the demand of elements. Coordinated regulation of P-glycoprotein activity and cytochrome P-4501A induction in sublines of rat hepatoma McA RH7777 cells with different levels of colchicine resistance.

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Three-dimensional mapping of spontaneous ventricular arrhythmias in a canine thrombotic coronary occlusion model. The present results indicated that the conformation of 1, 4-dihydropyridine-type calcium channel antagonists such as nilvadipine is easily changed by hydrogen bonds with water molecules of crystallization, and the water molecules are mobile through the void spaces formed between the layers in crystals. The modular series of various types were distinguished in the family of layered cuprates making use of the classification scheme in a fragment approximation developed earlier. Five untrained men performed a multiple-sprint test (10 x 7 s, with each sprint separated by 30 s) on each of four consecutive days (days 1-4), then rested for 6 d, and finally performed two additional tests on consecutive days (days 11 and 12).

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Spiritual peace predicts 5-year mortality in congestive heart failure patients. Hydrocortisone sensitivity: a prospective study of the value of tixocortol pivalate and hydrocortisone acetate as patch test markers. It is used often in patients with persistent neuropathic pain syndromes in an extremity, for instance following low back surgery. The c-MET (mesenchymal-epithelial transition factor) pathway is dysregulated in many human cancers and promotes tumor growth, invasion and dissemination.

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The results suggest that not only numerical but also experimental measurements of the deformation and SU-8 coating thickness in electro circuits are useful for enhancing structural stability. These data further demonstrate that excessive expression of the actin nucleation factor Spire is as deleterious for axon growth in vivo as is the loss of Spire, thus highlighting the need for a balance in the elementary steps of actin dynamics to achieve effective neuronal morphogenesis. Here, we report that two potential Cdk1 kinase phosphorylation sites are required for the chromosomal localisation of GFP::Cdc27 during mitosis.

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In maxillofacial surgery, predominantly radial underarm flaps and scapular or parascapular flaps are used. Twenty-four patients (24 percent) were rehospitalized within six months of discharge, and 44 (44 percent) were readmitted within 15 months. Our objective was to define the possibility of using oral-contrast-enhanced helical CT for the assessment of patients with cholecystolithiasis and of cholecystectomized symptomatic patients. When positive, therefore, tests for the presence of t-PA in human urine provide evidence for renal disease that may not otherwise be apparent. Transmission was probably associated with breaks in infection control practices, which occurred as single events from common sources or through a patient-to-patient route, likely the result of shared medications or supplies.

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Pregnancy causes a significant and sustained increase in cardiac output that may be poorly tolerated in cases of underlying heart disease. Establishing these models requires detailed attention to scientific, ethical, and medical principles to ensure the safety of the participants and their community contacts and to generate valid observations that can be generalized to natural infections. Genetical as well as experimental embryology methods have permitted, in recent years, to uncover a very important feature of mammalian embryonic development: it has been shown that female and male genomic complements are differentially imprinted in such a way that contribution of both a maternally and a paternally derived genome are absolutely necessary for the embryo to complete its normal development. graminearum was able to grow well at 26 to 28 degrees C, whereas F.