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Toplep (Topiramate)
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Topiramate

Toplep is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Toplep antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. Ras is switched from the inactive GDP-bound state to the active GTP-bound state by guanine nucleotide exchange factors (GEFs). We reviewed our experience with pneumonia in patients with lung cancer over a 14-year period at Kurume University Hospital. The qualitative changes of the intratumoral SWI patterns during a period of 4 weeks were quantified with the fractal dimension.

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A test statistic is proposed to compare two median residual lifetimes at any fixed time point. However, the properties of the enzyme crucial in conferring responsiveness have not yet been identified. However, the use of 5-ALA is complex and causes certain side effects. Housing, stress, and physical well-being: evidence from Thailand. In-silico pharmacodynamics: correlation of adverse effects of H2-antihistamines with histamine N-methyl transferase binding potential.

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Based on these results, it seems that the increased sTNFRs may act as an inhibitor to decrease the host immune response towards tumor cells in NPC patients. A comparison of paroxetine and placebo in depressed outpatients. Current trends toward nonuse of activated charcoal should be evaluated to determine whether patients poisoned by specific agents may benefit from activated charcoal administration.

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To study the effect of moxifloxacin versus imipenem/cilastatin (hereafter referred to as imipenem) treatment on the mortality of mice infected intravenously with different strains of Bacteroides fragilis and Escherichia coli. Nucleoside-diphosphate (NDP) kinase (NTP:nucleoside-diphosphate phosphotransferase) catalyzes the reversible transfer of gamma-phosphates from nucleoside triphosphates to nucleoside diphosphates through an invariant histidine residue. ALN generated stimulation control pulses, which correspond to the swing phase of the impaired leg when dorsal flexion of the foot is necessary to provide safe ground clearance. Thus, the structure of WATENG provides a capability to eliminate these two major interferences in a triboelectric self-powered sensor.

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Early results of treatment of tuberculous meningitis in children Survival of renal cell carcinoma metastatic to nonthyroid head and neck region: A systematic review. Medical history and Clinical evaluation was carefully performed by expert cardiologists. Medicare beneficiaries and to identify patient and hospital factors contributing to early vs late diagnosis of AAA. Delayed care of pelvic inflammatory disease as a risk factor for impaired fertility.

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The effect of tobacco smoking on clinical effectiveness of immunomodulatory treatment in multiple sclerosis patients We encourage use of the Villefranche classification and the associated criteria, although some of the manifestations could have been more accurately defined.

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The revision of critical nursing scholarship to address multicultural perspectives on critical thought will significantly transform nursing knowledge development. These results suggest that H2O2 signaling is under control of a signal transduction pathway that links the respiratory chain to the mitochondrial intermembrane space-localized, ubiquitous, and ancient Syk pathway in hematopoietic and nonhematopoietic cells. Small, atrophic breaks were detected in five of the eyes and were located in the base of the coloboma in four of the five eyes. Our aim was to evaluate the effects of the potent endogenous free radical scavenger melatonin on extracorporeal-shock-wave lithotripsy (ESWL) induced renal impairment.

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No viral RNA was detected in the lymphocyte-enriched nonadherent cell fraction. Obesity in childhood and adolescence is associated with health problems, increases in cardiovascular disease (CVD) risk factors and a greater likelihood of becoming overweight as an adult. The amplitude modulation of the N1 component predicted WM capacity in older adults, whereas the attentional amplitude modulation of the N2pc component predicted WM capacity in younger adults. Thus coupling to G(olf)alpha appears to mediate D1 signaling in the striatum.

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Chern semimetal and the quantized anomalous Hall effect in HgCr2Se4. Although fundoplication has been condemned in the past as treatment of achalasia to avoid the postoperative outcome of reflux, we have been successful with a partial fundoplication added to the standard esophagomyotomy. Genetic and environmental causes of variation in trait resilience in young people.

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The retention behaviour of several triacylglycerols (TAGs) and fats on Hypercarb, a porous graphitic carbon column (PGC), was investigated in liquid chromatography (LC) under isocratic elution mode with an evaporative light scattering detector (ELSD). In contrast, heat treatment of soil rarely affected enchytraeids, collembolans, or mites but frequently increased fungus numbers, regardless of mesh size.

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We conclude that the 4 strains were hemolytic variants of A lignieresii. Over a 12-year period, we treated 1014 consecutive pleural effusion patients, of whom 346 were diagnosed as having an idiopathic or malignant aetiology. Recently, there is growing molecular and biochemical evidence that other carbon sources, including fructose, may play a role in neuro-energetics. Moreover, all three members of the p160 family of nuclear receptor coactivators, SRC1, TIF2, and RAC3, are able to potentiate transcription from a TEF response element in transient transfection experiments, and this activation requires the presence of the bHLH-PAS domain. The human figure drawing test can be used as an additional measure of assessing intelligence in young children but it should not be substituted for standard tests.

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A procedure for purifying low-abundance protein components from the brain cytoskeleton-nuclear matrix fraction. Is there a growing role for endocrine therapy in the treatment of breast cancer? Bosentan, in addition to conventional therapy, has been shown to slow iPAH progression and improve clinical and haemodynamic status and symptomatology, compared with placebo and conventional therapy.

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As expected, meaning-making coping significantly mediated the effect of intrinsic religion (use of religion as a framework to understand life) on QoL. The dietary levels of zinc fed in a biotin-fortified egg white diet were: 0.7, 3.3, 5.9, 8.2, 11.0 and 31.4 mg/kg. The specific cases of a cell adhering to a homogeneous substrate and a heterogeneous bimaterial substrate are examined. This study aimed to verify the effects that corrective treatment for skeletal Class II malocclusions with fixed functional orthopaedic appliances has on the relative positions of the articular disc and the mandibular condyle. In reviewing the international literature, pulmonary involvement is not as rare as once was thought, and the diagnosis of TTP should be considered in the differential diagnosis of pulmonary-renal syndromes.

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The effect of vitamin A deficiency on the mitogen response of splenic B and T lymphocytes was determined in adult vitamin A-deficient rats. Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. Technical variation in metagenomic analysis must be minimized to confidently assess the contributions of microbiota to human health.

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Correlation between the size of the selenite-exchangeable metabolic pool and total body or liver selenium in rats. When the two current sources approach a recording electrode, a positive potential is recorded. A randomized clinical trial was conducted with 176 adults who were sedentary and overweight (mean body mass index, 34.0 kg/m(2)).

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This research shows it to be a significant issue in this relationship, for both groups of professionals. It was also observed, however, that plants expressing YFP-MPK6 displayed reduced apical dominance and a shortening of inflorescence internodes.

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The results of this study also support the requirement for thorough mixing during serial compound dilutions prepared for high-throughput lead optimization strategies using traditional liquid handlers. Hydrogen sulfide (H2S) could relax placental vasculature and improve intrauterine growth restriction. Amyotrophic lateral sclerosis (ALS) is a progressive and lethal disease of motor neuron degeneration, leading to paralysis of voluntary muscles and death by respiratory failure within five years of onset. Consequently, our particles gather the advantages of a well-defined structure, straight penetrating channels across the silica shell, and a high accessible porous volume of the central core.

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Mutations in the former tend to be dispersed throughout the gene and in other functionally related genes, whereas mutations in the latter are restricted to a few codons that seem to be very mutable. Whereas its presumed mode of action is inhibition of T cell/monocyte entry into the brain, little is known about its specific effect on B cells, which are increasingly recognized to participate in MS pathogenesis. Serum levels of the cytokines interleukin (IL)-1 beta , IL-6, IL-10, interferon (IFN)-gamma, and tumor necrosis factor-alpha and the chemokines macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and regulated upon activation, normal T cell expressed and secreted (RANTES) were measured in Ugandan children with CM, in children with uncomplicated malaria (UM), and in healthy children from the community, as control subjects (CCs). The OMS has the potential to assist in the initial diagnosis of HIV and in recognition of worsening disease.

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The physical and technical parameters of the units rated best were used to exemplify good radiographic practice. Two previous studies showed that red wine reduces fatty streak formation (early atherosclerosis) but not mature atherosclerosis in apolipoprotein (apo) E-deficient (apoE-/-) mice.

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The definition should be validated in other outbreaks and in situations where giardiasis must be distinguished from gastrointestinal disease caused by other agents. Silica has been proposed as the primary defence in grasses and is thought to lead to increased abrasiveness of foliage so deterring feeding, as well as reducing foliage digestibility and herbivore performance. Despite surgical efforts over a century, peritoneal adhesions are still an unsolved problem. Fighting the flu: developing sustained community resilience and preparedness.

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The effect of excess L-phenylalamine on mothers and on their breast-fed infants. We consequently considered it viable to conduct a clinical pharmacological study to evaluate the safety and efficacy of this histaminergic H3 agonist in migraine prophylactic treatment, which specifically may inhibit the neurogenic edema response involved in migraine pathophysiology. Numerous studies have assessed the socio-cognitive profile in Williams syndrome (WS) and, independently, in 22q11.2 deletion syndrome (22q11.2DS). The technique provides more predictable results in obturator fabrication as it uses silicone putty as the obturating material as opposed to sugar, asbestos, or other silicone rubber foams that can be messy, dangerous, and unstable. Most of the outbreaks have been associated to risky activities in bat-inhabited places.

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These preliminary data indicate that FDG/PET imaging of bladder cancer is feasible and it may provide new information for the diagnosis and staging of patients with bladder cancer. Relationship between peak torque and total work in an isokinetic contraction of the medial collateral ligament insufficient knee.

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Prediction of antisense oligonucleotide efficacy using aggregate motifs. Corticosteroids continue to be the preferred initial treatment, with the roles of radiation and nonsteroidal antiinflammatory medications to be determined. Smears of her otorrhea were negative for acid-fast bacilli but PCR of her otorrhea was positive. Previous work has established that 18-MC is a potent antagonist at alpha3beta4 nicotinic receptors. Disproportional myocyte growth is observed in pathologic concentric hypertrophy (myocyte thickening) and in eccentric dilated hypertrophy (myocyte lengthening).

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Action of chorionic gonadotropin in relation to the effects produced by chlorpromazine on testicles and seminal vesicles in experimental animals Aging in man is associated with alterations in food intake (FI) and body weight (BW). Nystagmus was analyzed for null-zone characteristics, waveforms, frequency, amplitudes, and slow-phase drift velocity during foveation.

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Five essential principles were identified and a total of 210 articles were included. Proposal for a standardized temporal scheme of biological classification for extant species. Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.

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Specific nutrition guidance can prevent abuses and can enhance the performance of the athlete and the team in many sports. Frequent nuclear expression of beta-catenin protein but rare beta-catenin mutation in pulmonary sclerosing haemangioma. Summary socio-demographic measures were derived from the 1996 Census. Controlled clinical trial of flufenamic acid in rheumatoid arthritis. Comparative evaluation of a retrospective study conducted in Lugano in 1995 with 85 women interviewed 3-6 months post-TOP, and a prospective study carried out in Geneva in 1998 with 103 women interviewed pre-TOP and 6 months post-TOP.

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However, studies on the effects of IP in cardiac surgery are rare and controversial. Interviews were audio-recorded, transcribed, and analyzed thematically. The reported incidence of ACL tears slightly increased from 0.081 to 0.084 per 100 players. Conversely, a second pool of synaptic vesicles that cannot be released by a single stimulus is recruited within milliseconds by high-frequency stimulation and support an ultrafast recovery of neurotransmitter release after low-frequency depression.

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MB 3683 was induced by the substrate and stimulated by methionine. Random priming digoxin (DIG)-labeled stx2-specific gene probe was prepared for Southern blot. We thus conclude that the length polymorphism in human Y chromosome may not be solely due to variations in the amount of Y chromosome-specific repeated DNA. Baroreceptor reflexes can modulate both pulmonary resistance and capacitance function and thus cardiac output. Co-determination of ATP and proteins in Triton X 100 non-ionic detergent-opened monolayer cultured cells.

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High-affinity binding of the basement membrane proteins collagen type IV and laminin to the gastric pathogen Helicobacter pylori. We also wished to determine the underlying cellular mechanisms of the effect. The Cw3-D227K mutant was indistinguishable from Cw3-wt in its ability to inhibit both natural cytotoxicity and ADCC mediated by human NK clones that have the appropriate CD158b inhibitory receptor. We report here a case of a maintenance hemodialysis patient with an acquired hair and skin fairness.

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At a group level, there is agreement between mean measured and predicted resting energy expenditure with the exception of the Harris-Benedict equation with an injury factor of 1.3. In the second group the myocardial fibrillary matrix was examined in different cardiopathies. Gradient parameters were correlated, but significant correlations between these parameters and certain variables such as the nematode species involved, the time interval between sampling and the last potato crop, soil type, cropping frequency, and cyst density in the focus center could not be demonstrated. The investigation revealed a demised fetus with the characteristics of 9 weeks of development.

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In the current study, we demonstrate that the signal transducer and activator of transcription 5 (Stat5) is rapidly activated by IgE cross-linkage, and that its expression is critical to the MC response. Gut gavage with antiendotoxin antibodies reduces the liberation of tumor necrosis factor-alpha after hemorrhage/resuscitation. A new piece of protective athletic equipment for the prevention of facial injuries to baseball players is introduced. Then, the NPY-IR cells and fibers in the TN system increased in density during late embryonic periods.

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A new alpha S1-casein allele in bovine milk and its occurrence in different breeds. Here, we investigated the effect of the dopamine system stabilizer aripiprazole on morphine-induced dopamine-related actions in mice. Studies on the presence of C-reactive protein during the pre- and neonatal period. Macrolide resistance in Mycoplasma genitalium in Female Sex Workers, Belgium.

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Ovarian response to human chorionic gonadotrophin and egg transport in the pregnant and post-parturient rabbit. The additional cost of rhTSH procurement and administration is considered relative to the clinical benefits and cost offsets. On the problem of the sanitation-index significance of enterococci in food products

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However, future multicenter trials should be performed to prove the predictive power of RI determination as a marker of renal function. Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus. Tumor necrosis factor and its p55 and p75 receptors are not required for axonal lesion-induced microgliosis in mouse fascia dentata. Furthermore, individual tissue glucose utilizations were similar in the two groups of rats, except in brown adipose tissue where utilization was lower in obese than in lean rats during the glucose challenge. Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system.

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The results demonstrate that implantation and clinical pregnancy rates with both media are comparable. (3) In the third scheme, using the biomimetic surface as part of signal transduction and combining both fluorescence self-quenching and energy-transfer mechanisms to enhance the signal transduction, a signal amplification was achieved. Eighteen cases of cerebral cavernous angiomas are reported, and their histopathological, clinical and radiological features are reviewed.

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The inhibition of the tumor proteasomal activity results in the accumulation of ubiquitinated proteins and ubiquitinated form of IkappaB-alpha, a natural proteasome substrate, followed by induction of apoptosis. The inclusive workplace: an ecosystems approach to diversity management. Efficient Cadmium Bioaccumulation by Displayed Hybrid CS3 Pili: Effect of Heavy Metal Binding Motif Insertion Site on Adsorption Capacity and Selectivity. Many-electron ground states in anisotropic parabolic quantum dots.

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Indeed, recent work indicates that tetracycline derivatives have the potential to interrupt the progressive connective tissue destruction that occurs in AAA, by virtue of their non-antimicrobial properties as MMP inhibitors, and they do so at clinically achievable dose schedules. Should patients with chronic renal insufficiency undergo carotid intervention? The fiber-optic imaging and manipulation of neural activity during animal behavior. Examinations of specific sites within the H2B tail domain indicate that this tail contains distinct structural elements and binds within nucleosomes with affinities that would reduce the activity of tail-binding proteins 10-50-fold from that deduced from peptide binding studies.

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The process of health care reform benefits tremendously from comparing characteristics and performance across nations. However, Ser142 mutant mice developed equal behavioural correlates of hyperalgesia as wild-type mice in different inflammatory models. Crow and Mange (1965) developed a method to estimate the inbreeding coefficient (F) through an ingenious surname analysis. Expression of CK20 mRNA was r fluoxetine prozac ingredients investigated by RT-PCR in bone marrow, portal vein and peripheral blood in 47 gastric, 58 colorectal cancer patients and 6 non-cancer volunteers.

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Victims of falls generally sustained fractures in more than one body region, and the number of injured regions correlates significantly with height. This study examined the financial costs of multiple sclerosis (MS) and the impact of financial strain on the subjective quality of life of people with MS and their families. In this article we report noroxin norfloxacin generic inhalation effects of nitrogen dioxide (NO2) and ozone (O3) mixture as well as O3 alone on blood-borne cancer cell colonization of lungs.

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A newly reported human polyomavirus, KI virus, is present in the respiratory mezcla de venlafaxina y alcohol tract of Australian children. Therefore, it is an excellent tool for in planta quantification of M. The proposed estimator uses a Gaussian far-field mean irradiance profile, and the irradiance pdf is assumed to be lognormal.

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Success and failure of colloidal approaches in adhesion of microorganisms to surfaces. Cytogenetic and oxidative status of human lymphocytes after exposure to clinically relevant concentrations clamovid breastfeeding twins of antimalarial drugs atovaquone and proguanil hydrochloride in vitro.

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The fine structure in the phosphorescence spectra at low temperature, with O,O vibrational bands centered at 405 nm and 415.5 nm dineurin 300 mg tramadol for both species, reveals a marked heterogeneity of the chromophore environment. A comparative study on the physicochemical and bacterial analysis of drinking, borewell and sewage water in the three different places of Sivakasi. These patients with transformed migraine exhibit mixed features of migraine and chronic tension-type headache. A prospective study was done in the Western Cape Province of South Africa, where tuberculosis and intestinal-parasite infection are common. Recent preclinical studies have shown that lithium (Li) robustly increases the levels of the major neuroprotective protein, bcl-2, in rat brain and in cells of human neuronal origin.

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Relating sensory profiles of canned amaranth (Amaranthus cruentus), cleome (Cleome gynandra), cowpea (Vigna unguiculata) and Swiss chard (Beta vulgaris) leaves to consumer acceptance. Additionally rN1-69 and rN1-28 detected seroconversions following vaccination with a killed virus preparation, faer pharmaceuticals cialis online even in the absence of a detectable virus neutralising response.

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Both microarrays and commercial ELISAs were utilized to detect serum antibodies against the ToRCH antigens in a panel of characterized human sera. Biomechanical properties were lower in SGL than in FGL at 8 d of age, but then bactrim side effects anxiety meds became higher in this line when compared at equal body weight. Delayed hypersensitivity response is controversial in selenium-supplemented rats and guinea-pigs.

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Cytologic, colposcopic, and virologic detection of cervical tryptanol medication list herpes simplex virus. The insurance level difference between two medical insurance schemes influences the treatment regimens and benefits received by patients.