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Endophthalmitis after ocular trauma carries a significantly worse prognosis, which may be reduced by early referral and intervention. Carbonic anhydrase activity has been demonstrated in the inner ear, and acetazolamide has been shown to affect the ion balance of the inner ear fluids. In LQT2 families, we identified three novel heterozygous HERG mutations (G965X, R1014PfsX39, V1038AfsX21) in the C-terminus that led to protein truncation and loss of a PKA phosphorylation site required for binding of 14-3-3epsilon.

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Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The primary drawback of midazolam is the potential for accumulation of the drug, which can result in prolonged sedation and a hangover effect. It appears that the inhibitory effects of forskolin were mediated by cAMP and not by its effects on the potassium channels because the 1,9-dideoxy derivative of forskolin which did not activate adenylate cyclase also did not suppress the generation of CTL. Neuronal loss in the hilar region was the most consistent finding in the hippocampal formation, similar to that found in the fluid-percussion model of traumatic head injury.

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Intensified daily dialysis: the best chronic dialysis option for children? Prevention of vitamin A deficiency and alimentary dystrophy in ducklings In addition to substantially preventing illness and complications from diarrheal disease in children, rotavirus infant immunization has the potential of indirectly preventing diarrheal disease in older children and adults, assuming children are the predominant sources of transmission. We studied the feasibility of assessing azygos blood flow with color Doppler endosonography and of monitoring the effects of vasoactive agents on azygos blood flow. Pilot data from the Spirale project -- follow-up of occupational respiratory exposures

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An update on nonsteroidal anti-inflammatory drugs (NSAIDs) in small animals. Plasma from women with preeclampsia has a low lipid and ketone body content--a nuclear magnetic resonance study. However, multisession radiosurgery may be required for aggressive chordomas. Constitutive expression of Notch3 in the peripheral epithelium in the developing lung resulted in altered lung morphology and delayed development, leading to perinatal lethality in these transgenic mice.

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morphine in patients undergoing thoracic or unilateral abdominal surgery. Depressed patients of the family physician often insist on somatic causes. One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.

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Protective effects of Abeta-derived tripeptide, Abeta(32-34), on Abeta(1-42)-induced phosphatidylinositol 4-kinase inhibition and neurotoxicity. A portion of children are born with Fetal Alcohol Spectrum Disorders (FASD). Part I: systematic review and meta-analysis in diabetes management. At 6 months follow-up the patient voided with a good stream and ultrasonography revealed complete disappearance of hydroureteronephrosis.

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MR studies were performed in 12 of these patients and the MR findings were correlated with the SPECT results. Ensuring that all relevant information is available and providing clinicians with further education and training would ensure that treatment decisions become more reliable, appropriate and targeted toward patient choice. Five cases involving the facial and cranial bones are described to illustrate the various presentations and radiological appearances including computerized tomography and magnetic resonance imaging.

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Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes. Time Course of Free Radicals Formation, Lipid Peroxidation, and Reoxygenation Injury in Perfused Rat Hepatocytes.

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The model was partially verified using experimental kinematic, torque, and electromyographic data from volunteer subjects performing both isometric and ballistic elbow joint complex movements. Oral squamous cell carcinoma (OSCC) has an aggressive behaviour with high incidence of nodal metastasis, even in the early stages, leading to poor prognosis. Although the initial randomized trials evaluating the efficacy of carotid angioplasty and stenting (CAS) relative to carotid endarterectomy (CEA) were favorable for CAS, more recent trials have not been universally supportive and have instead highlighted the fact that patient selection may be the key to reducing poor outcomes following percutaneous carotid intervention.

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The appearance and global spread in recent years of wave after wave of new and renewed infectious diseases and their entwinement with each other and with the social conditions and biopsychological consequences of disparity, discrimination, and structural violence has produced a new significant threat to public health internationally. A polyethylene cup explanted after 41 years was examined using several analytical techniques to determine whether there was a material cause for the extremely low wear observed. Titrated intracutaneous skin tests, skin prick tests, specific IgE assays, histamine release on washed leukocytes, and bronchial histamine and allergen-challenge tests were performed in 20 subjects with an intracutaneous skin test threshold for cat dander (Felis domesticus) or D. Percutaneous coronary intervention in patients with chronic renal insufficiency (CRI) and native coronary artery disease is often problematic, marred by increased morbidity and mortality rates and a high incidence of restenosis and revascularization. In one case a laryngeal metastasis represented the first manifestation of recurrent breast cancer.

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Electrostatic interactions between the polar head groups of the micelle and the cationic side chains of the peptides define the positions along the peptide backbone where the helical structures begin and end. Cutaneous metastases from renal cell carcinoma are rarely diagnosed during life. Subsequently, this domain becomes subdivided to form these three different structures under the influence of different inductive signals from surrounding tissues.

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Different velocity of heating under the ultrahigh-frequency field action was found for the head, chest and abdomen parts of adult bees. Torque teno virus (TTV) is a non-enveloped human virus with a circular negative-sense (approximately 3800 nucleotides) ssDNA genome.

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Significant findings in the past year include a greater understanding of dengue virus interactions with target cells such as dendritic cells, hepatocytes and endothelial cells. We conclude that asthma appeared to have been more common in athletes who participated in the 1998 Winter Games than in athletes who participated in either the 1996 or 1984 Summer Games. Flagellin, which is known to be a glycoprotein, was one of the proteins that showed altered reactivity with O:23 and O:36 antiserum in the mutants.

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PRX2 knockdown exacerbated neuronal death after oxygen and glucose deprivation. Pro-matrix metalloproteinase (pro-form of matrix metalloproteinase)-9 was strongly expressed during the early stages of wound healing (day 3).

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Habitual cannabis use has been shown to affect the human immune system, and recent advances in endocannabinoid research provide a basis for understanding these immunomodulatory effects. Inorganic arsenic, especially arsenic trioxide, has been demonstrated to induce clinical remission in patients with acute promyelocytic leukemia as well as those with several solid cancers.

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A novel mutation of the COMP gene in a Thai family with pseudoachondroplasia. Using the measurement option in the reconstruction program, the following trends emerged. MY APPROACH to the patient with an infected implantable cardioverter defibrillator (ICD).

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Action of snake venom phospholipase A on isolated platelet membranes. Exposure of the cells to H(2)O(2) could increase both Hsp32 and -47. Comparision of the mosquito saliva-capture enzyme-linked immunosorbent assay and the unicap test in the diagnosis of mosquito allergy. Poor nutrient status in RA patients has been reported and some drug therapies, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prescribed to alleviate RA symptoms, may increase the requirement for some nutrients and reduce their absorption. The neurologic effects of alcohol on physical and mental function vary in severity and reversibility.

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Magnetophoretic mobilities correlate to antibody binding capacities. Furthermore, we tested the feasibility of integrating the physical map with the existing soybean composite genetic map using 388 DNA markers.

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Doxycycline inhibits vascular leakage and prevents ovarian hyperstimulation syndrome in a murine model. The changed hemodynamic characteristics result in reduced cardiac index, and the renal perfusion is impaired with hyponatremia, and low renin and aldosterone production. The results for mitral valve reconstruction are compared with those for prosthetic mitral valve replacement. Inferior vena caval obstruction complicating vertebral column disease.

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The remaining 2 local serotypes (JO2 and JO3) did not react with any of the 20 IATS strains. This could be of value in the more convenient timing of treatment with invasive outpatient procedures. Despite this phenomenon, in no instance did therapy with a single agent eliminate the infection and eradicate the untargeted organism.

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Our observations support the notion that TNF-alpha is involved in UVB-induced keratinocyte apoptosis, and demonstrate that p55 receptor signaling plays a pivotal role in this event. Synthesis, antifungal activity and structure-activity relationships of vanillin oxime-N-O-alkanoates. Furthermore, serum levels of PrP (c) have recently been reported to be associated with the cognitive status of healthy elderly subjects. Restoration of facial animation and sensation is highly important for the outcome after facial allotransplantation. Production and characterization of an anti-serotonin 1A receptor antibody which detects functional 5-HT1A binding sites.

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Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. Particularly relevant are the magnitude of the water table rise and the grain size of the porous medium. Prior colonization is a major risk factor for candidemia, but few studies have focused on risk factors for colonization, particularly in NICU patients. The impact of maxillary osteotomy on speech outcomes in cleft lip and palate: an evidence-based approach to evaluating the literature. In addition to the base study groups, a supplemental group of rats at each exposure level was included to assess the effect of HDDC on reproduction.

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Species richness and evenness were significantly increased at restored sites, as were floodplain inundation frequencies. Prediction of outcome in twin pregnancy with first and early second trimester ultrasound. Moreover, it is also unclear whether the optimal duration of DAPT is similar for all DES types. Cigarette smoking continues to make an important impact on the health status and costs of care in the US.

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Metal-binding by pyridoxal derivatives and possible relationships to tryptophan metabolism. Although today staplers are extremely safe, efficient, and reliable, a potential risk exists for staple line failures, leading to three complications: leaks, fistulas, and bleeding.

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Complications in acute phase hospitalization of traumatic spinal cord injury: does surgical timing matter? The catalytic mechanism of dUTP pyrophosphatase (dUTPase), responsible for the prevention of uracil incorporation into DNA, involves ordering of the flexible C terminus of the enzyme.

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There were no differences in the organ distribution of caridac output between unoperated and sham-operated controls. If equine serum is collected, handled and stored anaerobically, and kept cold or frozen, Ca(I) concentration can be accurately measured for approximately 7 days after collection, regardless of the health status of the animal. Evaluation of our results in 30 patients revealed that although exposure to shock waves during ESWL for symptomatic renal calculi causes a slight increase in the urinary level of metabolites, all of these changes remained in normal range and no statistically significant changes in the urinary level of the aforementioned parameters could be demonstrated.

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In part because of the diverse clinical manifestations of LCH, there has long been controversy over whether LCH is best considered a reactive process or a neoplasm. Voluntary dislocation of the shoulder is rarely seen by primary care physicians, but they must be able to recognize it and treat it correctly.

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Phase I study of MLN8237--investigational Aurora A kinase inhibitor--in relapsed/refractory multiple myeloma, non-Hodgkin lymphoma and chronic lymphocytic leukemia. Retrograde pyelography revealed severe stricture of the right lower ureter. Targeting c-kit receptor in neuroblastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxins.

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We anticipate that MRI will help to make one more confident in the preoperative diagnosis of spinal subdural hematoma. The level of beta-actin mRNA was elevated in resting cells by epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate and to a lesser extent by fibroblast growth factor, insulin, and dibutyryl cyclic AMP-elevating agents.

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brucellosis in Niger is a serious problem among cattle especially in the rural areas around Niamey and among sheep in the urban areas of Niamey. To identify factors affecting stent occlusion after stent placement in the portal vein in patients with malignant portal vein invasion. Limited role of fetal blood sampling in prediction of outcome in intrauterine growth retardation. IESs are excised from micronuclear genes, and the MDSs are spliced when a micronuclear genome is processed into a macronuclear genome after cell mating.

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One patient was treated with streptokinase and five with urokinase. This system shows complete specificity of each recognition motif for its complementary unit, with no observable changes in the association constants regardless of the degree of functionalization.

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Pressure support ventilation in neonatal age: lights and shadows These findings validate and support the use of WSI to provide interpretation of FS in our network of affiliated hospitals and ambulatory surgery centers. Gambogic acid (2), a natural product isolated from the resin of Garcinia hurburyi tree, was discovered to be a potent apoptosis inducer using our cell- and caspase-based high-throughput screening assays. The accuracy of the results obtained also in this case revealed the robustness of the calculated pharmacophore model and led to the identification of the molecular structural moieties which are thought to contribute to the biological activity.

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Pluramycin complex with human serum albumin and the antitumor activity. The p53 protein also may act in part by regulating transcription but may also interact directly with the DNA replication apparatus. Effect of fasting on urinary calcium and hydroxyproline excretion in obesity. We aimed at developing a method for assessment and presentation of the 4D motion for multi-phase, contrast-enhanced cardiac CT data sets and demonstrating its clinical applicability. A gluten challenge in treated patients produced an altered staining pattern within 2 h.

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Blastocystis hominis: prevalence in asymptomatic versus symptomatic hosts. One hundred fifty patients underwent rigid ureteroscopy for stone extraction.

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The findings confirm that the implementation of water fluoridation has halved tooth decay in 5-year-old children and that the dental caries divide between rich and poor is reduced. We suggest that enhanced rate of proton transfer at high phosphate concentrations may be due to the dual proton donating and accepting nature of phosphate, in analogy to the Grotthuss mechanism for proton transfer in water. Blood samples for ACTH and cortisol determination were collected from each patient with diabetic nephropathy four times: before haemodialysis from the arterial line of dialyzer (0a) after 60 minutes of haemodialysis from the arterial (60a) and the venous (60v) line of dialyzer and after 240 minutes of haemodialysis from the arterial line (240a). Screening for mitochondrial DNA rearrangement disorders and sequencing relevant mitochondrial genes produced negative results. The contoured auricular projection graft provides a highly useful graft for the nasal tip.

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Pigments from natural sources has been obtained since long time ago, and their interest has increased due to the toxicity problems caused by those of synthetic origin. The results can be used for improvement of available high-productivity lines of ducks breeding of new lines, and promotion of the combining abilities of lines.