Zinacef axetil is an orally active prodrug of Zinacef. After oral administration, Zinacef axetil, as Zinacef, is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release Zinacef into the blood stream. Conversion to Zinacef, the microbiologically active form, occurs rapidly. The inherent properties of Zinacef are unaltered after its administration as Zinacef axetil. Zinacef exerts its bactericidal effect by binding to an enzyme or enzymes referred to as penicillin-binding proteins (PBPs) involved in bacterial cell wall synthesis. This binding results in inhibition of bacterial cell wall synthesis and subsequent cell death. Specifically, Zinacef shows high affinity for PBP 3, a primary target for Zinacef in gram-negative organisms such as E. coli.
Other names for this medication:
Cefuroxime,
Ceftum,
Zocef,
Cefakind,
Supacef,
Altacef,
Oratil,
Stafcure,
Pulmocef,
Zefu,
Ceftin,
Kefurox,
Zinacef,
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