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Targeted delivery of human pro-apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents. Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat: effect of pretreatment with phenobarbital. Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein. Air quality forecasts are now routinely used to understand when air pollution may reach unhealthy levels. The young rat with posterior destabilizing surgery was an appropriate animal model, mimicking the slippage and deformities radiographically seen in pediatric patients with spondylolysis.

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Ranging from surprise to pre-planning, several different levels of anticipation are explored. The use of liposomally-entrapped gentamicin in the treatment of bovine Staphylococcus aureus mastitis.

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Tertiary referral center for reproductive medicine and an IVF unit. Laparoscopic sleeve gastrectomy and medical management for the treatment of type 2 diabetes mellitus in non-morbidly obese patients: a single-center experience. In a multiple baseline across-subjects design, parents delivered a range of academic and nonacademic requests to their children to determine the probability of compliance for each request. Here we show that the study of such virulence factors can contribute to our understanding of not only virus pathogenesis but also the physiological role of cytokines.

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This is the first reported case of monomicrobial F necrophorum endocarditis in an adult. As for many other pathological issues, understanding the pathophysiological grounds of the condition to face greatly simplifies and accurately individuates the problem, to target the problem and help in reaching the therapeutic goal.

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Improved stearate phenotype in transgenic canola expressing a modified acyl-acyl carrier protein thioesterase. This new way of achieving and documenting quality will produce better outcomes for consumers and greater confidence in the value of substance abuse services, but first it will require new behaviors from all parties involved in the delivery of substance abuse prevention and treatment services. Bilateral MS cooling indicated that recovery of neglect can be induced by a restoration of the imbalance between activity levels of structures in both hemispheres and revealed an interaction between spontaneous and induced recovery of neglect. Inter- and intraspecific phylogenetic trees relating mtDNAs based on restriction maps, cytochrome b sequences obtained via PCR, and the two data sets combined were compared to one another statistically and were broadly similar except for the phylogenetic position of Pomatosomus halli.

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L-753,000 also potentiated the activation of mitogen-activating protein kinase signaling (downstream from Trk activation) by NT-3 in this cell line. We have identified acid sphingomyelinase (ASM) as an important player in the early and late anti-Salmonella activity of macrophages. An alternative design of locked percutaneous device for skeletal extension through skin. Over the 12 months of treatment there were 11 deaths (6 controls, 5 treated). When injected into the subcutaneous space of mice, luciferase expression was two to three orders of magnitude increased above the background.

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After some preliminary overoptimistic expectations, it seems clear now that genetics alone cannot transform medicine. Use of critical point polyacrylamide sols in thermal denaturation experiments with chromatin at physiological ionic strength. A single bolus of salbutamol was compared with a continuous aminophylline infusion in children with severe asthma in a randomised double blind study. A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate.

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In the sitting posture, individuals maintained their respective hand preference even when the food was on the other side of the body. A case of spino-cerebellar degeneration associated with carcinoma of the prostate. The lensing properties of this configuration are carefully investigated. These unique properties come from simply nanoporous structure and suggest new opportunity to innovative electrocatalysts in the future.

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Organisational and parental factors were not significant after adjustment. Characterization of the oxygenated intermediate of the thermophilic cytochrome P450 CYP119. Secondary infection affecting one of two simultaneously placed orbital wall implants.

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High-performance liquid chromatographic determination of PZ-peptidase activity. A right atrial hemangioma mimicking thrombus in a patient with atrial arrhythmias. Although these stresses inhibit translation and promote the movement of mRNAs into P-bodies, we also observed inhibition of deadenylation in cycloheximide-treated cells as well as in a mutant strain where translation initiation is impaired.

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Autophagy is a conserved mechanism for the degradation of cellular contents in order to recycle nutrients or break down damaged or toxic material. The advantages, disadvantages, and prospects for luminescent assays are discussed.

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Since these modules are involved with neuroprotection in Chrysemys picta bellii, the expression of MAPKs bears relative mechanisms of specific responses to hypoxia tolerance. RNAs homologous to these genes are abundant in the adult hermaphrodite, but missing from larvae and males.

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We demonstrate how a search with a single binding motif can be applied to explore gene regulatory networks and to discover coregulated genes in the genome. Comparison of Contrast Enhanced Ultrasound With Contrast Enhanced Computed Tomography for the Diagnosis of Hepatocellular Carcinoma. Our novel algorithm is applied on data obtained from a real experimental study and the identified subpathways provide biological evidence for the brain aging. Umbilical blood gas values and 1 and 5 min Apgar scores had much lower PPVs.

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Radiologists need to be alert to their presence when interpreting staging examinations in cancer patients. Successful treatment of bronchorrhea with octreotide in a patient with adenocarcinoma of the lung.

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The increased values of vitamin A, retinyl esters as well as its protein carriers and of vitamin E were probably a manifestation of enhanced protein and lipid synthesis in the liver as a result of albumin depletion. This technical comment accents on the perspectives for development of direct approach for investigation of function/flow coupling phenomenon and zinc transport into the brain, based on the current progress in development of ultra-fast molecular sensors for direct visualization of biochemical mediators and neurotransmitters, and high speed multi-photon deep-tissue imaging. The effects of within stimulus presentation rate and rise time on basic auditory processing were investigated in children with reading disabilities and typically reading children. Thymoquinone (TQ), a prominent constituent of Nigella sativa, has antioxidant, antiinflammatory, antiapoptotic, antimicrobial, and anticancer activity. We did not observe significant difference in the complication rates in the two methods of closure.

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Simultaneous CD4-T cell depletion and anti-PD-L1 blockade revealed that PD-L1 provided costimulation even in the absence of CD4-T cells. An investigation into the degree of activation and deactivation of AMPK subunits under exercise can provide valuable data for understanding AMPK. In 2 patients with a long lasting cortico-dependent chronic idiopathic thrombocytopenic purpura, splenectomy in one and ablation of an accessory spleen in the other, disclosed a complex association of splenoma, peliosis and lipidosis of the spleen, with a secondary sea blue histiocytosis in one case. The results were transposed to a new type of resistant starch (RS) produced by debranching maltodextrins in concentrated solutions. Prognostic factors of potentially severe presentations must be evaluated in order to facilitate the initial therapeutic choice.

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Arterial vessels behind the right internal jugular vein with relevance to central venous catheterisation. Despite the complex resuscitation care, the patients died due to consequences of haemorrhagic shock already during the operation or very soon after operation. More conservative preparations can be performed maintaining more tooth structure because of the adhesive properties of the composites and compomers.

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Altered thermoregulatory responses to clonidine in streptozotocin-diabetic rats. In this review we discuss cardiovascular mortality, incidence and prevalence of heart disease, and cardiac interventions and surgery in the Netherlands. Together, these data allow us to conclude that astrocytes in situ express vesicle proteins necessary for filling vesicles with the chemical transmitter glutamate and that astrocytes release glutamate through a vesicle- or fusion-related mechanism.

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In vitro testing indicated that bleomycin was more effective than Cisplatin and Doxorubicin when delivered using pulsed electric fields. While the repertoire of Me2N-directed reactions is growing at a rapid pace, the lack of a general method to transform this group to other functionalities hampers its wider application in organic synthesis. Progression of HOSE cells from a benign to an invasive phenotype in vitro may provide a model to dissect the progression of ovarian cancer. It exerts its effects by binding to the leukemia inhibitory factor receptor, a heterodimer of two transmembrane proteins, the specific leukemia inhibitory factor receptor subunit, and the common gp130. The changes in freshwater inputs and ocean storage occurred in conjunction with the amplifying North Atlantic Oscillation and rising air temperatures.

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Microscopic theory of vortex pinning: Impurity terms in the Ginzburg-Landau free energy. The interface strength was evaluated in terms of the extraction torque required to back out the screws. Given the intranasal delivery route of oxytocin to olfactory pathways and that olfactory abnormalities are a potential endophenotype in SZ, we investigated the effect of intranasal oxytocin on olfactory identification as well as positive and negative symptoms in people with schizophrenia.

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In the near future, new drugs and strategies for prevention and acute treatment will give physicians the tools for yet more productive interventions. Familiarity with the clinical signs of malignant melanoma can result in earlier recognition and thus potentially decrease both patient morbidity and mortality. To assess the presence of matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP (TIMP-1) in peritoneal fluid and serum of subjects with and without adhesions. Tobacco consumption and secondhand smoke exposure in vehicles: a cross-sectional study.

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However, few studies have explored the interactions of EPO with the immune system. Data collected were clinical history, physical examination and lateral skull X-ray, along with QOL survey by using obstructive sleep apnea-18 (OSA-18) questionnaires. Differences in amino acids composition and coupling patterns between mesophilic and thermophilic proteins. After killing both meniscectomized and contralateral TMJ specimens were sectioned sagittally and prepared for light and scanning electron microscopy studies. Recognizing the message and the messenger: biomimetic spectral analysis for robust speech and speaker recognition.

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Hospital food samples contained Salmonella typhimurium, Campylobacter jejuni (biotype 1) and enteropathogenic Escherichia coli, suggesting that food might have been the vehicle for these infections. Genetic kidney diseases disclose the pathogenesis of proteinuria.

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isolates as determined by National Committee for Clinical Laboratory Standards method M27-A and two other methods. Twenty-six patients with an average age of 43 years were treated with Achilles tendon allograft interposition for failed distal ulnar resection. Macrolides are indicated for the treatment of atypical pneumonia. A reliable biological marker for measuring cellular aging is telomere length, which is maintained by a specialized form of cellular polymerase known as telomerase. Changes in osmotic pressure in the presence of dextrose up to 0.3 M had no significant effect on the size of these micellar nanostructures.

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In clinical practice, the definition of neuroanatomic subtypes provides little contribution specifically to PSD prediction after a first-ever ischemic stroke. This study investigates the role of Fas-linked motoneuron death in the pathogenesis of ALS. We investigated rates and correlates of unintended pregnancies among HIV-positive women of reproductive age.

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Representative, population-based epidemiologic data for gastroenteritis caused by rotavirus (RV) are rare. DNA evidence on the phylogenetic systematics of New World monkeys: support for the sister-grouping of Cebus and Saimiri from two unlinked nuclear genes.

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People with chronic mental illness present complex challenges for the design of health care financing reforms. Role of the nurse in hemodynamic tests and monitoring at the bedside Microsurgical reversal of a 1-2cm segment of mid ampulla was performed in rabbits.

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Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy. Autologous blood or commercially available fibrin glue was poured into the otic bulla after artificial rupture of the round window. For this net power, leakage levels considerably less than 5 mW/cm2 (at 5 cm from applicator-phantom boundary) were obtained for the applicators in direct contact with the phantom. In contrast, APOBEC3A, APOBEC3C and APOBEC2 are monomers at all tested concentrations. Spontaneous mutational specificity of drug resistance plasmid pKM101 in Escherichia coli.

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Statistical analysis of tubal sterilization according to Madlener-Pomeroy during the last 10 years (1951-1960) The UVC irradiation of harvested grapes could prevent germination of contaminant fungi during storage or further dehydration. MRI showed reconstitution of the tendon into the patellar defect with no evidence of bone formation. This subglottic almost circumferential MALT lymphoma showed a temporary distinct disappearance after cortisone administration during the diagnostic process.

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Dynamic changes in mineral metabolism indexes in coronary atherosclerosis patients during diet therapy In contrast, beta2 integrins induced stimulation of Cdc42 that was independent of Src family members. Binding energetics of the inhibitor cystatin to the cysteine proteinase actinidin.

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We report an adult patient with cerebral aneurysmal arteriopathy who presented shortly after his AIDS-defining illness in a setting of severe immune suppression and high viral load. The questionnaire consisted of four parts: demographic characteristics, factors affecting violence, areas of violence (physical, emotional, sexual) and maternal and fetal outcomes. Infection of microglia may disturb the normal hemostatic balance that exists between microglia and other glia, and between microglia and neurons, processes that are only recently being explored at the molecular level. Twenty tumors of the peripheral sympathetic nervous system were investigated using a spectrum of antibodies against vimentin, neurofilament triplet, S-100 protein, neuronal specific enolase (NSE), chromogranin, synaptophysin, and vasoactive intestinal polypeptide. We describe here the development and use of a reverse genetics strategy for FIPV based on targeted RNA recombination that is analogous to what has been described for the mouse hepatitis virus (MHV) (L.

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We used a Likert-type questionnaire with 26 statements and one open-ended question. AFP-L3 levels were measured by lectin-affinity electrophoresis coupled with antibody-affinity blotting. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis. We have presented a case in which flow cytometry of pleural fluid was applied in the diagnosis of an AIDS-related lymphoma. The association of metformin and a dose of NPH does not obtain suitable control in patients with a long evolution who have already received two or more OADs.

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Treatment of Abdominal Segmental Hernia, Constipation, and Pain Following Herpes Zoster with Paravertebral Block. Administrations of sodium selenite did not change these parameters in normal rats. In this case report we describe a 55 year-old woman admitted to our emergency department first with the impression of seizure. We studied the electroclinical sequence of these manifestations and their correlation with electrocardiogram (ECG), and we compared seizures with or without IA among the same patients. Stented patients had the double J removed between postoperative day 3 and 10 (mean 7).

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The hybrid film thus obtained showed remarkable anisotropic photoelectronic properties due to the confinement effect of the oriented mesochannels. A relationship between sex hormones and chronic daily headache (CDH) is less well established. Automated Ilizarov distraction is more safe method of orthopedic leg lengthening than manual distraction in points of nervous fibers survival and articular cartilage arthrotic changes.

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Analysis of conserved microsatellite sequences suggests closer relationship between water buffalo Bubalus bubalis and sheep Ovis aries. Change in the biological properties of salmonellae in acquiring resistance to chloramphenicol Our goals were to evaluate relative extinction risk among populations in two different watersheds (in Tennessee, U.S.A.) and potential effects of variation in managed river flow on population dynamics. A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium currents by dopamine in rat lactotrophs. The concordance of TST and QuantiFERON-TB gold in-tube (QFT-IT) was high (kappa 0.73 in Brazil and 0.80 in Nepal).

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Photochromic molecules provide an intriguing and relatively untapped alternative to traditional materials utilized in organic memory devices. In transplant recipients, intensification of immunosuppressive therapy to treat allograft rejection poses a major risk factor for IA. Chemotherapy comprising a combination of uracil and tegafur with mitomycin C achieved a complete response in the patient which lasted for approximately four years. The antibodies were quantified by ELISA using microtitre plates coated with crude gliadin fractions.

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Various MR protocols using signal intensity ratio and mainstream relaxometry methods have been used, sometimes with discrepant results. Estimation and confounder control was performed with multiple, logistic regression. A 15-item questionnaire was mailed to 985 physicians who either were Society of American Gastrointestinal Endoscopic Surgeons (SAGES) candidate members or had attended a SAGES resident course in 1998 or 1999. According to our view, the detection of the lung cancer, particularly in those at high risk, is a by-product of periodic chest x-ray aiming at early detection of tuberculosis, however, mass screening for lung cancer as public health measure is not recommended. Antigenic and cellular localisation analysis of the severe acute respiratory syndrome coronavirus nucleocapsid protein using monoclonal antibodies.